Chemistry & Biochemistry

Permanent URI for this communityhdl:10365/32416

Research from the Department of Chemistry & Biochemistry. The department website may be found at https://www.ndsu.edu/chemistry/

Browse

Browsing Chemistry & Biochemistry by Subject "Cinchona alkaloids."

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    The Development and Use of Chiral 4-Dimethylaminopyridine-N-Oxide as an Organocatalyst
    (North Dakota State University, 2018) Joyce, Jesse Jo
    Organocatalysis is a field that has bloomed over the last decades. With the field’s promise of being able to mimic nature and afford products in a synergistic manner to traditional Lewis acid catalysis, several interesting discoveries have been made. Owing to the vastness of the field as it exists today, this document will focus on two main aspects; cinchona alkaloid (and derivatives) as used in common carbon-carbon bond forming reactions and kinetic resolution via 4-dimethyl aminopyridine-N-oxide derivative driven acylation. Kinetic resolution via organocatalysis has the potential to react one enantiomer of a racemic mixture without affecting the other. The highlight of this screening was an s factor of 9 which was produced using optimized conditions using a catalyst designated DMAPO-IV. There remains much to do in improving the system and elucidating the scope of this catalytic system this report details the efforts made thus far.