Microbiological Sciences

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Research from the Department of Microbiological Sciences. The department website may be found at https://www.ndsu.edu/micro/

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Browsing Microbiological Sciences by browse.metadata.type "Master's Paper"

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    The B-Cell Role in Autoimmunity
    (North Dakota State University, 2023) Mindt, Marissa Marie
    This review is focused on B-cell’s role in autoimmunity and was conducted by reading current papers across a variety of journals and compiling the information learned in this process. Specifically, this review paper encompasses an analysis of what autoimmune diseases are, as well as some of the characteristics of autoimmune diseases the introduction section of this paper serves as a crash course on B-cell. The disease write-up is where autoimmune diseases that are affected and mediated by B-cells, such as systemic lupus erythematosus, multiple sclerosis, and Chron’s disease, are explored. The next section will compare the mechanisms behind each of the diseases to explain how B-cells can cause a large variety of symptoms as well as highlight what symptoms overlap and why. Treatment options and current research are covered throughout this paper to display an understanding of how these diseases are combated.
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    Current Status of the Biology, Pathogenesis, and Impacts of Ebola Virus
    (North Dakota State University, 2021) Alamri, Dalal
    Ebola viruses (EV) are single-stranded negative-sense RNA viruses belonging to the Filoviridae family. There are 6 species of Ebola, and four of them can cause Ebola virus disease (EVD) in humans. Ebola viral hemorrhagic fever is one of the deadliest diseases known to infect humans and non-human primates. The primary mode of transmission of Ebola has been identified as direct contact with infected animals, humans and body fluids. The early diagnosis of EVD is difficult because of similarities of the initial disease presentation to influenza-like symptoms such as high fever, myalgia, fatigue, headache, and chills. The most common symptoms that have been reported from previous outbreaks were fever, sore throat, abdominal pain, vomiting, bleeding, diarrhea, and chest pain. Several methods have been used to detect Ebola such as ELISA, conventional RT-PCR, and real-time RT-PCR. Scientists have been working on several therapeutics and vaccines to prevent and treat Ebola.
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    The Decomposition Ecology and Microbial Forensics of the Postmortem Microbiome
    (North Dakota State University, 2021) Ewald, Adam Patrick
    Every living organism dies and is decomposed into nutrients and by-products. This is lead initially by the normal flora of the newly deceased host. The postmortem microbiome, so-called “necrobiome”, undergoes temporal changes affected by the environment in the carcass. The increased data on the necrobiome is fueled by recent advances in genome sequencing analysis techniques. Metagenome sequencing analyzes temporal changes in a population. Genotypic information elucidates identity, structural, and functional traits across a biome. Initially, the necrobiome is composed of taxa common to the living tissue. As decomposition progresses, new and unique taxa emerge. Those suited for growth in the specific environment become dominant. Alpha diversity, beta diversity, and community traits are used to analyze the necrobiome. The necrobiome has potential for forensic evidence predictions. This review covers the succession of the necrobiome specific to body location, their effect on the decomposing carcass, and potential forensics uses of the necrobiome.