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Now showing items 24831-24840 of 28637
Effects of Environmental Estrogens on the Growth Hormone-Insulin-Like Growth Factor System in Rainbow Trout (Oncorhynchus Mykiss)
(North Dakota State University, 2013)
The increasing production, use, and disposal of an expanding array of chemicals that enter the environment pose a serious threat to terrestrial and aquatic animals, as well as to humans. Fish in aquatic habitats are exposed ...
Nos1-Adaptor Protein Dysfunction in the Nucleus Tractus Solitarii Contributes to the Neurogenic Heart Damage and Qt Interval Prolongation
(North Dakota State University, 2015)
Variants of the Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP) locus are strongly related to QT interval prolongation and sudden cardiac death (SCD) in human. Neurogenic cardiac damage due to subarachnoid hemorrhage, ...
Anticancer Mechanisms of Flaxseed and its Derived Mammalian Lignan Enterolactone in Lung
(North Dakota State University, 2017)
Whole flaxseed and its derived lignans have shown anti-cancer properties in a variety of malignancies. However, their potential remains uninvestigated in lung cancer, the leading cause of cancer-related deaths worldwide. ...
Mechanisms of Piperlongumine-Induced Cancer Cell Death
(North Dakota State University, 2015)
Piperlongumine (PPLGM), a bioactive agent obtained from long pepper plants, possesses
potent antitumor activity by inducing reactive oxygen species (ROS). However, the mechanisms
for PPLGM’s antitumor actions are not well ...
Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)
Autophagy, a conserved catabolic process required for cellular homeostasis in
eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to
investigate conformational flexibility of autophagy ...
Nutritional Regulation of Growth Hormone-Stimulated Lipolysis
(North Dakota State University, 2014)
Growth hormone (GH) regulates several physiologic processes in vertebrates, including the promotion of growth, an anabolic process, and mobilization of stored lipid, a catabolic process. Here, we used rainbow trout ...
Immunomodulatory Role of B Lymphocytes and Hyaluronic Acid in a Murine Model of Allergic Asthma
(North Dakota State University, 2012)
In the world today, asthma affects more than 235 million people. The widespread prescription of inhaled corticosteroids—the current gold standard of asthma control medication—allows many asthmatics to live symptom-free and ...
The Role of Platelet-Derived Growth Factor Receptor Signaling in Medulloblastoma Metastasis
(North Dakota State University, 2013)
Medulloblastoma is the most common brain tumor in children and one third of the patients remain incurable. Tumor metastasis is one of the primary reasons for its high mortality rate. Despite evidence of overexpression of ...
The Discovery of a Novel Growth Hormone Receptor and the Nutritional Regulation of the Growth Related Actions of Growth Hormone
(North Dakota State University, 2017)
The growth hormone (GH) family peptides such as GH, prolactin (PRL), and somatolactin (SL) regulate a wide array of physiological actions including but not limited to growth, metabolism, osmoregulation, and lipolysis. These ...
Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction
(North Dakota State University, 2012)
Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability ...