This paper examines the flow of a Newtonian modeled blood through axisymmetric sudden expansion geometry. Reynolds number of 500, 2000, 3500, 5000, and 6500 are examined using laminar, shear stress transport, and base line analysis solvers using ANSYS 14.0. Simulation data sets are then examined against experimental data sets provided by the FDA. Results of the solution sets indicate that the laminar case set (Re = 500) is well predicted by the laminar solution set, while the fully turbulent flow (Re = 6500) is well predicted by the shear stress transport solver. Simulation and comparison of transitional cases lead to moderate discrepancies from the experimental data.