Respiratory infectious diseases are among the leading cause of morbidity and mortality in the world. This paper presents two respiratory diseases, Mycobacterium bovis and Streptococcus pneumoniae, which cause significant global health issues despite the advancement of vaccines. In Uganda, M. bovis isolates (n=27) were PCR-tested for a specific chromosomal deletion (RDAf2) and spoligotyped for specific characterization of the Af2 clonal complex. Seventeen (63%) isolates contained the Af2 clonal complex. The high prevalence indicates Af2 clonal complex is of epidemiological interest and a likely cause of bovine tuberculosis in Kampala, Uganda. Ten vervet serum (varying age groups) levels were measured (Luminex) for the immunoglobulin G (IgG) antibody response against the 23-valent, Pneumovax 23® (PN23), pneumococcal capsular polysaccharide serotypes when simultaneously administered with F1/V plague vaccine and Influenza vaccine. Subjects 9-11 years and 25-26 years have shown a slightly better immune response (11%) to PN23 serotypes compared to 19-23 year subjects.