The adoption of connected and autonomous vehicles (CAVs) is in its infancy. Therefore, very little is known about their potential impacts on traffic. Meanwhile, researchers and market analysts predict a wide range of possibilities about their potential benefits and the timing of their deployments. Planners traditionally use various types of travel demand models to forecast future traffic conditions. However, such models do not yet integrate any expected impacts from CAV deployments. Consequently, many long-range transportation plans do not yet account for their eventual deployment. To address some of these uncertainties, this work modified an existing model for Madison, Wisconsin. To compare outcomes, the authors used identical parameter changes and simulation scenarios for a model of Gainesville, Florida. Both models show that with increasing levels of CAV deployment, both the vehicle miles traveled and the average congestion speed will increase. However, there are some important exceptions due to differences in the road network layout, geospatial features, sociodemographic factors, land-use, and access to transit.