Electric and autonomous aircraft (EAA) are set to disrupt current cargo-shipping models. To maximize the benefits of this technology, investors and logistics managers need information on target commodities, service location establishment, and the distribution of origin–destination pairs within EAA’s range limitations. This research introduces a three-phase data-mining and geographic information system (GIS) algorithm to support data-driven decision-making under uncertainty. Ana- lysts can modify and expand this workflow to scrutinize origin–destination commodity flow datasets representing various locations. The algorithm identifies four commodity categories contributing to more than one-third of the value transported by aircraft across the contiguous United States, yet only 5% of the weight. The workflow highlights 8 out of 129 regional locations that moved more than 20% of the weight of those four commodity categories. A distance band of 400 miles among these eight locations accounts for more than 80% of the transported weight. This study addresses a literature gap, identifying opportunities for supply chain redesign using EAA. The presented methodology can guide planners and investors in identifying prime target markets for emerging EAA technologies using regional datasets.