Therapeutic ultrasound has been well documented in the literature to affect human tissue. The four main parameters practitioners are able to influence are frequency, duty cycle, intensity, and treatment time. Alteration to one or more of these parameters will affect the total dose of acoustical energy delivered to the tissue resulting in a target tissue temperature increase or biophysical effect. The goal of this two-part study was to determine the appropriate energy dose of therapeutic ultrasounds needed to create a beneficial intervention when treating unhealthy human tissue. Prior to the investigation a non-systematic review was conducted to determine the dose-response and thermal outcome in laboratory studies. The first investigation used a systematic intervention component analysis (ICA) to determine the effectiveness and empirical relationship between the different parameters of an ultrasound intervention when treating unhealthy tissue. The second investigation included a four-part survey which addressed trends within parameter selection in the clinical setting and influences on clinical decision making. The first investigation findings indicated no one parameter had significant influence on the ultrasound treatment effectiveness. The second investigation findings indicated practitioners set a treatment goal of 2℃ and a mean predictive outcome between 1.85 and 2.56℃ regardless of the condition.