Taylor, Andrew James David2018-03-022018-03-022015https://hdl.handle.net/10365/27648Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.NDSU Policy 190.6.2https://www.ndsu.edu/fileadmin/policy/190.pdfThesis0000-0002-1075-4485