NDSU North Dakota State University
Fargo, N.D.

NDSU Institutional Repository

Discovering Complex Relationships between Drugs and Diseases

Show simple item record

dc.description.abstract Finding the complex semantic relations between existing drugs and new diseases will help in the drug development in a new way. Most of the drugs which have found new uses have been discovered due to serendipity. Hence, the prediction of the uses of drugs for more than one disease should be done in a systematic way by studying the semantic relations between the drugs and diseases and also the other entities involved in the relations. Hence, in order to study the complex semantic relations between drugs and diseases an application was developed that integrates the heterogeneous data in different formats from different public databases which are available online. A high level ontology was also developed to integrate the data and only the fields required for the current study were used. The data was collected from different data sources such as DrugBank, UniProt/SwissProt, GeneCards and OMIM. Most of these data sources are the standard data sources and have been used by National Committee of Biotechnology Information of Nation Institute of Health. The data was parsed and integrated and complex semantic relations were discovered. This is a simple and novel effort which may find uses in development of new drug targets and polypharmacology.
dc.title Discovering Complex Relationships between Drugs and Diseases en_US
dc.date.accessioned 2012-01-26T19:29:17Z
dc.date.available 2012-01-26T19:29:17Z
dc.date.issued 2012-01-26
dc.identifier.uri http://hdl.handle.net/10365/19223
dc.subject Drug development -- Data processing.
dc.subject Drugs -- Design -- Data processing.
dc.subject Semantic Web.
dc.subject Data mining.
dc.thesis.degree Paper (M.S.)--North Dakota State University, 2011.
dc.contributor.advisor Li, Juan
dc.creator.author Sharma, Ranjana
dc.degree.departmentCollege Master of Science / Computer Science, College of Science and Mathematics, 2011.
dc.date.created 2011

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


Your Account