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Evaluation of a Climate-Sensitive Disease Control Strategy and Investigation of Multi-drug Resistance in Infectious Bacterial Diseases: A US-Africa Experience

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dc.contributor.author Mukiibi, Herbert
dc.description.abstract This paper presents two research projects that explore avenues of controlling infectious diseases both in Africa and the United States. In Uganda, a retrospective study of Otuboi Sub County patient data to evaluate the impact of Stamp Out Sleeping sickness (SOS) intervention was performed. Polymerase Chain Reaction to detect the conjugatively transferred virulence factors from MDR E. coli to Salmonella was performed in North Dakota. Human African Trypanosomiasis prevalence was significantly reduced at intervention year (2006) compared to the pre-intervention years; 2004 (P = 0.00024) and 2005 (P = 0.000001). Of the 22 screened virulence factor genes, eight genes were PCR detected in MDR E. coli 2077 isolate. Six of the detected genes were found to be received by Salmonella transconjugates. The protective effect of SOS intervention was sustained for only two years (2007 and 2008) post intervention. MDR E.coli 2077 isolate conjugatively transferred its virulence factors to Salmonella strains. en_US
dc.title Evaluation of a Climate-Sensitive Disease Control Strategy and Investigation of Multi-drug Resistance in Infectious Bacterial Diseases: A US-Africa Experience en_US
dc.date.accessioned 2012-11-09T18:02:31Z
dc.date.available 2012-11-09T18:02:31Z
dc.date.issued 2012-11-09
dc.identifier.uri http://hdl.handle.net/10365/22222
dc.subject Virulence (Microbiology) en_US
dc.subject Drug resistance in microorganisms. en_US
dc.subject Communicable diseases -- Control. en_US
dc.subject African trypanosomiasis -- Microbiology -- Uganda. en_US
dc.subject African trypanosomiasis -- Transmission -- Uganda -- Prevention. en_US
dc.subject Escherichia coli -- Microbiology -- North Dakota. en_US
dc.subject Escherichia coli -- Transmission -- North Dakota -- Prevention.
dc.subject Communicable diseases -- Transmission -- Uganda -- Prevention.
dc.subject Communicable diseases -- Transmission -- North Dakota -- Prevention.
dc.thesis.degree Paper (M.S.)--North Dakota State University, 2012. en_US
dc.contributor.advisor Gibbs, Penelope
dc.degree.departmentCollege Master of Science / Veterinary and Microbiological Science, College of Agriculture, Food Systems, and Natural Resources, 2012.
dc.date.created 2012

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