Development of novel asymmetric and catalytic methods for synthesizing small organic molecules containing hindered quaternary and tertiary centers is a major challenge and a dynamic area of investigation in synthetic organic chemistry. The incorporation of these chiral centers into small molecules such as cyclopropanes, aziridines or isoxazolidines is important because they are present in a large number of biologically active natural products as well as in synthetically designed pharmaceutical agents. However, the synthesis of non-natural compounds containing quaternary and tertiary centers that have potential as therapeutics are scarce due to the limited number of readily available methods. We have successfully used 1-(benzyloxy)imidazole as a new bidentate coordinating template for dipolar cycloaddition and cyclization reactions using chiral Lewis acid as a promoter to access these highly functionalized small molecules in high yields and selectivity. Chapter 1. Review for Michael Initiated Ring Closure (MIRC) reaction. The chapter provides different diastereo- and enantioselective strategies for the construction of chiral cyclopropanes. Also, the chapter will provide the current methodologies developed for MIRC reaction. Chapter 2. Development of a novel chiral Lewis acid methodology for synthesizing highly strained cyclopropanes with chiral quaternary and tertiary centers using Michael Initiated Ring Closure (MIRC) reaction for β-substituted and β,β-disubstituted enones with N-benzyloxy imidazole as an achiral template. Different types of nucleophiles such as sulfur ylides and bromomalonate were successfully employed in the MIRC reaction. Chapter 3. Development of a novel chiral Lewis acid methodology for synthesizing highly strained chiral CF3-substituted aziridines using aza-Michael initiated ring closure reaction (aza-MIRC). The reaction involves β,β-disubstituted enones with N-benzyloxy imidazole as an achiral template and N-nosyloxy carbamate as ‘nitrene’ source. Chapter 4. Development of N-benzyloxy imidazole template as a chelating scaffold for chiral Lewis acid catalyzed enantioselective nitrone cycloaddition of β,β-disubstituted enones for the construction of isoxazolidines with trifluoromethyl group is described. The N-benzyloxy imidazole in the cycloadduct was efficiently transformed into corresponding isoxazolidine ester, which could be further converted into useful precursors such as β-hydroxycarbonyls, 1,3-diols, β-aminoalcohols, β-aminoacids, β-lactams and other functionalized building blocks.