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Dual Functionalized Liposomes for Co-delivery of Anti-cancer Chemotherapeutics for Treatment of Brain Tumor
(North Dakota State University, 2019)
Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Currently available treatment options are insufficient to increase median survival time. The combination therapy has emerged ...
Inhibition of Nitric Oxide Signaling by Melatonin in Porcine Coronary Arteries
(North Dakota State University, 2012)
This research represents an effort to bridge a critical gap in the understanding of the local effects of melatonin on the coronary circulation. The first objective was designed to identify the specific melatonin receptor ...
Epigenetic Regulation of Apoptosis in Prostate Cancer
(North Dakota State University, 2015)
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the polycomb repressive
complex 2 and suppresses gene expression by catalyzing histone H3 methylation on lysine 27.
EZH2 is overexpressed in metastatic ...
Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries
(North Dakota State University, 2016)
Video summarizing Ph.D. dissertation for a non-specialist audience.
A Numerical and Analytical Analysis of the Physics of Phase-Separation Fronts
(North Dakota State University, 2012)
My dissertation is an investigation into the basic Physics of phase separation fronts. Such phase-separation fronts occur in many practical applications, like the formation of immersion precipitation membranes, Temperature ...
The Potential Inhibitory Effect of Dihomo-Gamma-Linolenic Acid on Colon Cancer Cell Growth via Free Radical Metabolites in Cyclooxygenase-Catalyzed Peroxidation
(North Dakota State University, 2012)
Cyclooxygenase (COX) can metabolize dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) through free radical-mediated lipid peroxidation to form the anti-carcinogenic 1-series of prostaglandins and pro-carcinogenic ...
Buckling Instabilities of Nanoscale Polymer Films and Colloidal Particle Layers
(North Dakota State University, 2015)
Nanoscale polymer films have numerous potential applications such as protective
coatings, flexible electronics, energy harvesting devices, and drug delivery systems. For
realization of these potential applications, the ...
Free Energy Minimization and Multicomponent, Multi-Phase Lattice Boltzmann Simulations of Van Der Waals Fluid Mixtures
(North Dakota State University, 2018)
In this thesis, we develop a general framework for the lattice Boltzmann method to simulate multiphase systems with an arbitrary number of components. Theoretical expectations are easily visualized for binary mixtures, so ...
Knockdown of Delta-5 Desaturase to Elicit Anti-Cancer Effect of Dihomo-γ-Linolenic Acid: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)
Pancreatic cancer is one of the most common causes of cancer death in the United States. Unlike ω-3 fatty acids, which have been commonly used as complementary therapy to treat pancreatic cancer, ω-6s (more abundant fatty ...
Synthesis and Evaluation of Cationic Nanomicelles for In Vitro and In Vivo Gene Delivery
(North Dakota State University, 2013)
The goal of proposed study was to contribute towards the development of a nano size, high efficiency and low toxicity non-viral polymeric vector for gene delivery in vitro and in vivo. A series of fatty acid grafted ...