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Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)
(North Dakota State University, 2013)
The Receptor for Advanced Glycation End products (RAGE) interacts with several classes of structurally unrelated ligands. The activation of RAGE by its ligands results in the cellular activation of several kinases and ...
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)
Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ...
Developing Management Tools for Sunflower Rust (Puccinia Helianthi)
(North Dakota State University, 2013)
Sunflower rust, caused by Puccinia helianthi (Schwein), is an economically important disease in North Dakota. Since 2008, sunflower rust incidence and severity have increased. Therefore, a four year study was initiated to ...
Understanding and Managing Rhizoctonia Solani in Sugarbeet
(North Dakota State University, 2013)
Rhizoctonia crown and root rot of sugarbeet (Beta vulgaris L.) caused by Rhizoctonia solani Kühn is one of the most important production problems in Minnesota and North Dakota. Greenhouse studies were conducted to determine ...
Genetic Structure of Leptosphaeria Maculans Populations in North Dakota and Identification of Genes Associated with Resistance to L. Maculans in Brassica Juncea
(North Dakota State University, 2013)
Blackleg, caused by Leptosphaeria maculans is one of the most devastating diseases of canola (Brassica napus) in North Dakota. A study was conducted to characterize prevalence of pathogenicity groups (PG), identify population ...
Characteristics and Host Range of a Novel Fusarium Species Causing Yellowing Decline of Sugarbeet
(North Dakota State University, 2013)
In 2008, a novel and distinct Fusarium species was reported in west central Minnesota causing early-season yellowing and severe decline of sugarbeet. This study was conducted to (i) establish optimum conditions for fungal ...
Lung Mucosal Response to Repeated Inhalational Insults with Immunomodulatory Agents in a Murine Model of Fungal Asthma: Airway Epithelium Takes the Center Stage
(North Dakota State University, 2013)
Asthma is a debilitating disease of the lungs affecting 235 million people worldwide. Fungus-associated asthma leads to a particularly severe type of disease, and exposure to environmental fungi and their products is ...
Investigations in Asthma Heterogeneity: The Roles of Aspergillus Fumigatus-Derived Eicosanoid Synthases and Occupational Exposures to Grain Dusts on the Development of Fungal Allergic Asthma
(North Dakota State University, 2013)
Allergic asthma is an inflammatory syndrome of the respiratory system which changes the airway wall architecture. Using an aeroallergen, murine model of A. fumigatus-mediated asthma, the two studies herein examine the ...
Happy Beef: The Development of ß-Phenylethylamine as a Novel Nutrient Treatment Reducing Bacterial Cell Count by Escherichia Coli O157H7 on Beef Meat
(North Dakota State University, 2013)
Since its emergence in 1980's, Escherichia coli O157:H7 has often been associated with the consumption of contaminated meat. E. coli O157:H7 continues to persist as a food borne pathogen not only in beef but many other ...
Inhibition of Fusarium Growth and Trichothecene Accumulation in Grain by Antifungal Compounds from Lactic Acid Bacteria
(North Dakota State University, 2013)
Fusarium head blight (FHB) is a widely occurring plant disease, which is caused by fungi in the genus Fusarium. FHB leads to mycotoxin accumulation on grain, which causes food safety risk and economic loss. In addition to ...