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Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation during DNA Repair and Checkpoint Adaptation in Saccharomyces Cerevisiae
(North Dakota State University, 2018)
In response to DNA damage, a signaling cascade is activated within cells that promotes cell cycle arrest in order to provide adequate time for DNA repair to occur. Replication Factor A (RFA) is an essential, heterotrimeric ...
New Strategies for Transition Metal Catalyzed C-C and C-N Bond Formation
(North Dakota State University, 2018)
Transition metal catalysis emerged as an essential tool in the field of organic chemistry. In this context, transition metal catalyzed C-H bond functionalization is considered as an alluring strategy as it occurs with the ...
Achiral Templates in Asymmetric Catalysis: Applications in Construction of All Carbon Quaternary Centers
(North Dakota State University, 2018)
Conjugated olefins are readily available and inexpensive starting materials and their functionalization offers a rapid access to many important building blocks for organic synthesis. The functionalization of these olefins ...
Synthesis and Applications of Dialdehydes
(North Dakota State University, 2018)
Due to their reactivity and ease of functional group interconversions, aldehydes have wide-ranging applications in polymer synthesis, such as polyacetals, epoxy resins, and polyurethanes. Recently, room temperature synthesis ...
Telomere Correlations during Early Life in a Long Lived Seabird
(North Dakota State University, 2018)
Telomere dynamics in blood cells have been linked to aging in a variety of organisms. However, whether blood telomeres correlated with telomeres in other parts of the body is not well known, especially during early life ...
Personality and Behavioral Syndromes of the Big Brown Bat, Eptesicus fuscus
(North Dakota State University, 2018)
As the study of animal personality has significant expanded in the last decade, a growing amount of research has focused on the impacts of sociality and group dynamics on behavioral repeatability. The research presented ...
Testosterone (T) and Triiodothyronine (T3) in Franklin’s Gull (Leucophaeus Pipixcan) Eggs
(North Dakota State University, 2018)
Maternally-derived hormones are known to influence the growth and development of offspring. The differential deposition of these maternally-derived hormones into egg yolk is one way by which females can alter and impact ...
Understanding Binding-Induced Disorder-to-Order And Conformational Transitions in Proteins that Regulate Autophagy
(North Dakota State University, 2018)
Autophagy, a cellular homeostasis process that degrades and recycles cytosolic contents, is regulated at various stages by protein interactions. BECN1 regulates autophagy through interactions with diverse proteins via ...
Synthesis of Precursors to Non-isocyanate Polyurethanes
(North Dakota State University, 2018)
Biobased diamines are excellent precursors for the synthesis of non-isocyanate polyurethanes (NIPUs). We have prepared several biobased diamines using three different reactions for their synthesis. In the first method, we ...
Functionalization of Heterocycles: A Metal Catalyzed Approach via Allylation and C-H Activation
(North Dakota State University, 2018)
The central core of many biologically active natural products and pharmaceuticals contain N-heterocycles, the installation of simple/complex functional groups using C-H/N-H functionalization methodologies has the potential ...