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Understanding the Role of the Receptor for Advanced Glycation End-Products (Rage) in Pancreatic Cancer
(North Dakota State University, 2019)
Expression of the Receptor for Advanced Glycation End Products (RAGE) and is upregulated in a several cancers. Based on published studies, we hypothesized that RAGE, when overexpressed in pancreatic cancer cells, will ...
Dual-Functionalized Liposomes for Gene Delivery to Brain to Prevent and Treat Alzheimer’s Disease
(North Dakota State University, 2019)
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder which lacks effective disease-modifying therapies. We have investigated the therapeutic potential of pDNA encoding apolipoprotein E2 (ApoE2), ...
Plant-Parasitic Nematodes on Sugarbeet in North Dakota and Minnesota
(North Dakota State University, 2019)
Field surveys were conducted in the Red River Valley (RRV) of North Dakota and Minnesota during 2016 and 2017 to determine the incidence, abundance, and distribution of plant-parasitic nematodes (PPNs) on sugarbeet. ...
Efficacy of Chlorine Dioxide Fumigation on the Spores of Paenibacillus larvae, the Causative Agent of American Foulbrood Disease in Honeybees
(North Dakota State University, 2019)
Honeybees (Apis mellifera) play a critical role in agricultural pollination. However, their health and numbers are in decline. A major cause of this decline is bacterial diseases, of which American foulbrood disease (AFB) ...
Heterogeneity in Phenotypic Response of Foodborne Pathogens to Control Measures
(North Dakota State University, 2019)
Foodborne pathogens are estimated to cause 48 million foodborne illnesses through consumption of contaminated food annually. Designing efficient control measures is vital to reducing foodborne illnesses. The modern trend ...
Interactions of Aspergillus fumigatus and Pseudomonas aeruginosa Contribute to Respiratory Disease Severity and Death
(North Dakota State University, 2019)
The lung was recently identified to consist of a complex microenvironment made up of microorganisms that interact with one another and the host cells via direct and indirect interactions. As a result, understanding the ...
Phenotypic and Genomic Assessment of Listeria monocytogenes Virulence
(North Dakota State University, 2019)
Listeria monocytogenes is the etiological agent of listeriosis in humans and ruminants causing bacteremia, central nervous system (CNS) infections, abortion, and gastroenteritis among other clinical outcomes. Recent studies ...
Characterizing the Impact of Stress Exposure on Survival of Foodborne Pathogens
(North Dakota State University, 2019)
Bacterial pathogens transmitted by the fecal-oral route endure several stresses during survival/growth in host and non-host environments. For foodborne pathogens, understanding the range of phenotypic responses to stressors ...
Population Structure of Uromyces appendiculatus in North Dakota
(North Dakota State University, 2019)
North Dakota is the lead producing state of common bean in the USA, accounting for 43% of national production. Bean rust is caused by the autoecious, macrocyclic fungus Uromyces appendiculatus (Pers.:Pers.). All pathogen ...
Cloning and Characterization of rcs5, Spot Blotch Resistance Gene and Pathogen Induced Nec3 Gene Involved in Programmed Cell Death in Barley
(North Dakota State University, 2019)
Upon sensing pathogens, plants initiating defense responses typically resulting in programmed cell death (PCD). PCD effectively subdues biotrophic pathogens but is hijacked by necrotrophs that colonize the resulting dead ...