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Now showing items 3231-3240 of 4247
Interactions of the Receptor for Advanced Glycation End Products (Rage) with Advanced Glycation End Products (AGEs) and S100B
(North Dakota State University, 2016)
RAGE is a multi-ligand pattern recognition receptor. RAGE can bind several damage associated molecular pattern proteins. RAGE- ligand interaction is pathophysiologically relevant to several major diseases including diabetes ...
Detection of Metalloenzymes Employing Fluorescentpolymers and Liposomes
(North Dakota State University, 2012)
In the biological systems, proteins are important constituents. Protein-protein interactions play vital roles in physiological environments and any disruption in these interactions lead to adverse effects. However, designing ...
Drug Delivery Systems for Treatment of Diabetes Mellitus
(North Dakota State University, 2019)
Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive ...
Dual Modified Liposomes for Drug and Gene Delivery to Brain
(North Dakota State University, 2014)
The overall goal of our research was to design a vector for efficient delivery of therapeutic genes/drugs to brain. Specifically, this research work was focused on designing PEGylated liposomes surface modified with the ...
Development and Characterization of Multifunctional Nanoparticles for Drug Delivery to Cancer Cells
(North Dakota State University, 2014)
Lipid and polymeric nanoparticles, although proven to be effective drug delivery systems compared to free drugs, have shown considerable limitations pertaining to their uptake and release at tumor sites. Spatial and temporal ...
Understanding the Role of the Receptor for Advanced Glycation End-Products (Rage) in Pancreatic Cancer
(North Dakota State University, 2019)
Expression of the Receptor for Advanced Glycation End Products (RAGE) and is upregulated in a several cancers. Based on published studies, we hypothesized that RAGE, when overexpressed in pancreatic cancer cells, will ...
Dual-Functionalized Liposomes for Gene Delivery to Brain to Prevent and Treat Alzheimer’s Disease
(North Dakota State University, 2019)
Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder which lacks effective disease-modifying therapies. We have investigated the therapeutic potential of pDNA encoding apolipoprotein E2 (ApoE2), ...
Smart, Biocompatible Polymersomes for Targeted Delivery of Therapeutic Agents to Cancerous Tumors
(North Dakota State University, 2017)
Chemotherapeutics are the major treatment options for cancer. Although we cannot underestimate the importance of the chemotherapeutic drugs, their systemic toxicity is an important limiting factor for their use. Therefore, ...
Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)
(North Dakota State University, 2013)
The Receptor for Advanced Glycation End products (RAGE) interacts with several classes of structurally unrelated ligands. The activation of RAGE by its ligands results in the cellular activation of several kinases and ...
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)
Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ...