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Now showing items 2521-2530 of 3438
Smart, Biocompatible Polymersomes for Targeted Delivery of Therapeutic Agents to Cancerous Tumors
(North Dakota State University, 2017)
Chemotherapeutics are the major treatment options for cancer. Although we cannot underestimate the importance of the chemotherapeutic drugs, their systemic toxicity is an important limiting factor for their use. Therefore, ...
Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)
(North Dakota State University, 2013)
The Receptor for Advanced Glycation End products (RAGE) interacts with several classes of structurally unrelated ligands. The activation of RAGE by its ligands results in the cellular activation of several kinases and ...
Mir-627 Mediates the Epignetic Mechanisms of Vitamin D in Suppression of Colon Cancer Growth
(North Dakota State University, 2013)
Low circulating vitamin D levels have been linked to increased risks of cancer by epidemiologic studies, and preclinical research has demonstrated clear antitumor activities of vitamin D against various types of cancers. ...
Electrostatic Interactions at Dielectric Interfaces: From Colloids to Membranes
(North Dakota State University, 2017)
In this thesis we have investigated electrostatic interactions at dielectric interfaces using theoretical models based on the non-linear Poisson-Boltzmann theory and its extensions. We have focused on three major topics: ...
Multi-Scale Simulation Methods of Crosslinked Polymer Networks and Degradation
(North Dakota State University, 2018)
Crosslinked thermoset polymers are used heavily in industrial and consumer products, as well as in infrastructure. When used as a protective coating, a thermoset's net-like structure can act as a barrier to protect an ...
The Nature of Single-Wall Carbon Nanotube-Silicon Heterojunction Solar Cells
(North Dakota State University, 2015)
Since their inception in 2007, nanotube-silicon heterojunction solar cells have experienced rapid improvement due to the diligent work of several research groups. These devices have quickly reached a point where they might ...
Guiding Self-Assembly of Functionalized Nanoparticles by Computational Modeling of Effective Interactions
(North Dakota State University, 2018)
Nanoparticles have attracted much attention because of their unusual physical properties, which allow them to be used in many practical applications. The self-assembly of nanocrystals into crystalline arrays can be facilitated ...
Computational Modeling of Polymer Crowding: Influence of Solvent Quality and Dimensionality on Conformations
(North Dakota State University, 2018)
The structure and function of polymers in confined environments, e.g., biopolymers in the cytoplasm, are affected by macromolecular crowding. To explore the influence of solvent quality and dimensionality on conformations ...
A Novel Macroscopic Technique to Measure the Nanomechanics of Durable Multifunctional Nanosheets
(North Dakota State University, 2017)
In the recent advancement of nanotechnology, carbon nanotubes (CNTs) have shown promise and potential for a wide variety of applications due to their excellent mechanical, electrical, and optical properties. A network of ...
Genetic and Molecular Characterization of Genes Involved in Barley-Cochliobolus Sativus Interaction
(North Dakota State University, 2015)
Spot blotch caused by ascomycete fungus Cochliobolus sativus (Ito & Kurib.) Drechs. ex Dastur. [anamorph: Bipolaris sorokiniana (Sacc.) Shoem.] is one of the most common and economically important diseases on barley. To ...