This research program investigates the performance of a steel truss bridge when subjected to both localized web damage and a subsequent post-tensioned strengthening approach. The investigation utilizes a combined approach involving an experimental scale model bridge and a numerical computer model generated using the commercial finite element software RISA 3-D. The numerical model is validated using test data and further extended to parametric studies in order to investigate the theoretical load rating, strain energy, load redistribution, mode shapes and frequency of the bridge for control, damaged and strengthened states. The presence and severity of damage are found to significantly influence the global safety and reliability of the bridge. Also, higher order modes are more susceptible to changes in shape and frequency in the presence of damage. A recovery of truss deflection and a reduction of member forces are achieved by the proposed strengthening method.