| dc.contributor.author | Woodard, Alycia Maureen | |
| dc.description.abstract | Diet-induced obesity (DIO) has been shown to increase DNA methyltransferase (DNMT)
expression and DNMT binding at obesity-associated genes. Natural compounds have the
potential to reverse obesity-associated gene expression via the regulation of DNA methylation.
The objective of this study was to determine the effect of the bioactive compounds of flaxseed on
DNMT and obesity-associated gene expression. Sixty C57BL/6J male mice were randomly
assigned into one of the following diet groups and fed for eight weeks: 45% kcal fat; 45% kcal
fat, 10% whole flaxseed; 45% kcal fat, 6% defatted flaxseed; 45% kcal fat, 4% flaxseed oil; and
16% kcal fat. DNMT1, DNMT3a, DNMT3b, leptin, and peroxisome proliferator-activated
receptor (PPAR)-α expression levels in muscle and adipose tissues were determined by real-time
PCR.
The results indicate that bioactive compounds of flaxseed affect selected gene expression.
Further research is needed to identify the specific mechanisms regulating leptin or PPAR-α
expression during DIO development. | en_US |
| dc.publisher | North Dakota State University | |
| dc.rights | NDSU Policy 190.6.2 | |
| dc.title | The Role of Flaxseed in the Expression of DNA Methyltransferases, Leptin, and Peroxisome Prolifterator-Activated Receptor Alpha in an Obese Animal Model | en_US |
| dc.type | Thesis | en_US |
| dc.date.accessioned | 2018-04-03T19:10:22Z | |
| dc.date.available | 2018-04-03T19:10:22Z | |
| dc.date.issued | 2016 | en_US |
| dc.identifier.uri | https://hdl.handle.net/10365/27924 | |
| dc.rights.uri | https://www.ndsu.edu/fileadmin/policy/190.pdf | |
| ndsu.degree | Master of Science (MS) | en_US |
| ndsu.college | Human Sciences and Education | en_US |
| ndsu.department | Health, Nutrition and Exercise Sciences | en_US |
| ndsu.advisor | Rhee, Yeong | |
