The first study was conducted during 2014 growing season at Glyndon, MN to evaluate the effectiveness of nitrification inhibitor or both urease and nitrification i.e. double inhibitors on reducing N losses in a rainfed spring-wheat (Triticum aestivum L.) system. Our findings suggested that amending urea with double inhibitors might be an effective strategy to reduce all possible N losses without compromising crop yields from urea-fertilized soils. The second study was conducted to understand the responses of spring-wheat to sulfate-based salinity stress under greenhouse and field conditions. Results from the greenhouse study indicated that the threshold soil ECe (EC using saturated-paste-extract method) affecting grain and straw yields were 8.2 and 2.9 dS m-1, respectively. However in fields, crop roots were subjected to heterogeneous salinity and the preferential root-growth in the least saline surface 0-60 cm soil layers resulted in greater salinity-tolerance to crops than that observed in a greenhouse study.