The effects that radio frequency (RF) energy has on the body is currently an inconclusive and controversial topic. This is in part due to the differences and issues that can be found in previous studies. This thesis describes a study on the effect of continuous RF energy on the genome of in vivo mouse brain tissue for a duration of 31 days. To address the issues found in previous studies a new standardized procedure was followed. The genome of the brain tissue was quantified using RNA-seq and then analyzed using statistical combinations and empirical pvalues. Transcripts with their respective p-values were uploaded into Integrity Pathway Analysis® to determine genes associated disease and function within the brain tissue. The results from this study provided evidence that supports RF energy induces changes in the genome. Additionally, the results provided evidence of the first reported case of a potential RF-controlled genetic transistor.