OBJECTIVE: To examine the efficacy of patient-reported outcome measures in the physically active and to determine whether a relationship exists between general health-related quality of life and specific outcome measures. Instruments used were the DPA, the SF-36, the QuickDASH, and the ASES. METHODS: 42 NCAA Division I athletes completed outcome measures three separate times. Repeated-measures ANOVA was performed and bivariate Pearson correlations were calculated. Additionally, test-retest reliability and minimal detectable change were assessed. Significance was set at α ≤ 0.05. RESULTS: Significant relationships were found between the DPA and several subscales of the SF-36. Participation in physical activity did not have an effect on scores as measured at different time points. CONCLUSIONS: The DPA and SF-36 are effective measures of health in physically active populations. The QuickDASH and ASES may not be reliable measures in these populations.