Utilizing a social construction perspective, this study uses a mixed method approach to examine the opioid epidemic. The study begins by identifying the numerous claims-making groups along with conducting a content analysis of the rhetoric and symbols used to legitimize the claims about the opioid epidemic. The data for the content analysis was obtained through a search of the websites, newsrooms, and pressrooms of claims-making groups. Additionally, the study examines and assesses the volume of money that is generated and allocated towards opioid research and prevention in an effort to determine who has more power to influence the policy initiatives. Findings show that the frequency of rhetoric and the number of claims-making groups releasing information about the opioid epidemic increased from 2010-2016. Most of the rhetoric consists of groups proposing resolution strategies and formulating new policies. Only a few claims-makers are making financial contributions towards opioid prevention initiatives and in most cases, it is a very small amount of money.