The beef industry continues to face concerns regarding the hygiene and the safety of its products. A wide range of microorganisms from various sources can grow on meat surfaces that are rich in fluid and nutrients. This paper was conducted to better understand the common spoilage microflora and the most threatening foodborne pathogens (E. coli O157:H7 and Salmonella spp.) in ground beef and the role of the virulence factors that allow pathogens to persist in the host. In addition to the above, this paper addresses the effects of using antimicrobial interventions on the ground beef products. Despite using innovative antimicrobial interventions to eliminate or reduce spoilage bacteria and common foodborne pathogens, there is still a need for new antimicrobial technologies to control the industry’s sanitary hurdles and to understand their affects on meat quality and sensory characteristics.