| dc.contributor.author | Kusick, Emma Claire | |
| dc.description.abstract | Asthma is a debilitating lung disease that affects nearly 300 million people worldwide. Environments with high humidity and subsequent mold exposure often trigger allergic asthma. Sex differences have been reported in the incidence, prevalence, and severity of asthma. B-lymphocytes are recruited in high numbers to the allergic lung in response to the inhalation of Aspergillus fumigatus mold spores (conidia). In this work, we used a mouse model of allergic fungal asthma to assess environmental humidity, sex, and B-lymphocytes in an inhalational model of allergic fungal asthma. Our results showed that animals sensitized in low humidity conditions had no airway hyperresponsiveness (AHR), inflammation, but an increase in IgG3 antibody production. Males weighed more than females, female mice had more fibrosis and produced more IgG3 Ab, but sex showed no impact on low humidity. C19+ B-lymphocytes differentially downregulated multiple genes related to allergic asthma returning the body to homeostasis. | en_US |
| dc.publisher | North Dakota State University | en_US |
| dc.rights | NDSU policy 190.6.2 | en_US |
| dc.title | Characterizing Humidity, Sex, and B-Cell Gene Regulation in Fungal Allergic Asthma | en_US |
| dc.type | Thesis | en_US |
| dc.date.accessioned | 2021-03-16T16:25:20Z | |
| dc.date.available | 2021-03-16T16:25:20Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/10365/31802 | |
| dc.subject | asthma | en_US |
| dc.subject | b-cell | en_US |
| dc.subject | fungus | en_US |
| dc.subject | humidity | en_US |
| dc.subject | mice | en_US |
| dc.subject | sex | en_US |
| dc.identifier.orcid | 0000-0002-0367-5367 | |
| dc.rights.uri | https://www.ndsu.edu/fileadmin/policy/190.pdf | en_US |
| ndsu.degree | Master of Science (MS) | en_US |
| ndsu.college | Agriculture, Food Systems and Natural Resources | en_US |
| ndsu.department | Microbiological Sciences | en_US |
| ndsu.advisor | Schuh, Jane | |
