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Now showing items 21-30 of 42
4-Dimethylamino Pyridine (DMAP) Catalyst with Fluxional Chirality: Synthesis and Applications
(North Dakota State University, 2016)
Organocatalysis using small organic molecules to catalyze organic transformations, has
emerged as a powerful synthetic tool that is complementary to metal-catalyzed transformations
and remarkably promote stereoselective ...
Attempted Total Syntheses of a Novel Lycopodine-Class Alkaloid and (R)-Myricanol, Compounds for the Treatment of Alzheimer's Disease
(North Dakota State University, 2013)
Alzheimer's Disease (AD) is a significant challenge to both the pharmaceutical world as well as the synthetic organic chemistry world. One of the most important problems in this field is the lack of a unified approach to ...
Novel Synthetic Routes to Complex Amines: the Catalytic Hydroamination of Alkynes and Hydroimination of Allenes
(North Dakota State University, 2016)
Amines are valuable targets for synthesis in contexts of both research and industrial applications. This work proposes two atom-economical methods—hydroamination (HAM) and hydroimination (HIM)—as C-N bond formation strategies. ...
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)
Light is an environmentally benign and renewable source of energy that finds wide application in
the field of science. This dissertation explores two areas of chemistry that utilizes light extensively viz.,
asymmetric ...
Structural Studies of the Mechanism by Which BCL-2 and Beclin Proteins Regulate Autophagy and Apoptosis
(North Dakota State University, 2016)
Autophagy and apoptosis are catabolic pathways essential for homeostasis in all eukaryotes. While autophagy usually promotes cell-survival by enabling degradation and recycling of damaged macromolecules, apoptosis is the ...
Interactions of Light with Organic Chromophores: A Photochemical and Photophysical Investigation
(North Dakota State University, 2018)
Over the past century, light has emerged as a useful tool finding utility in various fields such as device fabrication, the medical field, as well as utility as an energy source. Chemist have adopted this abundant energy ...
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)
Alkynes are versatile and valuable synthetic precursors in a variety of organic
transformations and have found tremendous applications in materials science and pharmaceutical
chemistry. In recent years, there has been a ...
Stereospecific Photochemical Transformations Involving Axially Chiral Acrylanilides and a-Oxoamides
(North Dakota State University, 2013)
Asymmetric photochemical transformations have been under-explored due to the ineffectiveness of conventional methodologies/reagents/catalysts (point chiral auxiliaries and inductors) that were generally employed for thermal ...
New Strategies for Ruthenium Catalyzed C-C Bond Formation
(North Dakota State University, 2014)
Transition metal-catalyzed C-H bond activation allows direct functionalization of the ubiquitous C-H bonds in organic molecules to increase the molecular complexity. Since Murai's pioneering work in ruthenium catalyzed ...
Novel Asymmetric Approaches for Construction of Small Molecules by Cyclization and Cycloaddition
(North Dakota State University, 2015)
Development of novel asymmetric and catalytic methods for synthesizing small organic
molecules containing hindered quaternary and tertiary centers is a major challenge and a
dynamic area of investigation in synthetic organic ...