Browsing Chemistry & Biochemistry Doctoral Work by Title
Now showing items 12-31 of 67
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Characterization of RPA2 N-terminal Function in the DNA Damage Response in Saccharomyces Cerevisiae
(North Dakota State University, 2015)In response to DNA damage, two general but fundamental processes occur in the cell: (1) a DNA lesion is recognized and repaired, and (2) concomitantly, the cell halts the cell cycle to provide a window of opportunity for ... -
Delineating Signaling Mechanisms Involved in Lymphocyte Chemotaxis, Immune Homeostasis and Allergic Asthma
(North Dakota State University, 2015)The vasoactive intestinal peptide (VIP) signaling axis constitutes VIP and its two G protein coupled receptors (GPCR) termed vasoactive intestinal/pituitary adenylate cyclase activating polypeptide (VPAC) 1 and 2. This ... -
Designing Ru Catalysts for Selective C-H Bond Oxidation Reactions
(North Dakota State University, 2020)Typically, C-H bond oxidation proceeds via formation of high-valent metal oxo species. Attaining a high oxidation state of the metal complex is critical as it is the key step for many catalytic processes. Understanding ... -
Development of Quantitative Lateral Flow Strip Biosensors for the Detection of Cancer Biomarkers
(North Dakota State University, 2019)The detection of cancer biomarkers is of great importance in oncology. Cancer biomarkers can provide diagnostic information which can aid disease screening and early diagnosis. Further, cancer biomarkers can help predict ... -
Differential Modulation of the Structural and Functional Characteristics of Human Matrix Metalloproteinase Isozymes upon Binding to Different Ligands
(North Dakota State University, 2010)Matrix metalloproteinases (MMPs) are a family of Zn2 + -dependent, Ca2 + -containing endoproteinases involved in tissue remodeling and degradation of the extracellular matrix (ECM). Human MMP isozymes are known to be ... -
Effect of Surface Ligands and Surface Defects on the Electronic and Optical Properties of Quantum Dots
(North Dakota State University, 2016)Quantum dots (QDs) have drawn a special attention since recent past due to their properties such as broad range absorption ability, size tunable narrow emission, high extinction coefficients, and charge carriers ability. ... -
Enhanced Sensitivity of Lateral Flow Strip Biosensors Based on Enyzmatic Reaction and Nanomaterials
(North Dakota State University, 2014)Ultrasensitive detection for trace amount of proteins plays pivotal role in the diagnosis of specific diseases in clinical application, basic discovery research and the improvement of proteomics. Recently, lateral flow ... -
Enzyme Behavior in Synthetic Materials and Structural Implications for Rational Design
(North Dakota State University, 2020)Combining enzymes with synthetic materials is the new frontier of biocatalysis, materials science, and protein engineering. Enzymes are biological macromolecule catalysts with incredible efficiency and specificity that are ... -
Examining Thieno[3,4-b]pyrazine Through a Multifaceted Lens: From Extended Ring Functionalization to Ambipolar-Acceptor Copolymers
(North Dakota State University, 2022)A class of materials known as conjugated polymers (CPs) has been shown to integrate the physical properties of organic plastics such as low-weight, flexibility, and synthetic modularity with electronic semiconducting ... -
Exciton Diffusion, Transport, and Localization in Conjugated Polymers
(North Dakota State University, 2013)Conjugated polymers are wide bandgap semiconductors which have a series of conjugated π-orbitals that extend along the polymer ‘backbone’. The π-orbital conjugation can be disrupted by twisting of the polymer, affecting ... -
Exploitation of Biomass for Applications in Sustainable Materials Science
(North Dakota State University, 2019)Biorefinery may be defined as the process of accessing chemical commodities from living systems; consequently, biomass becomes the antecedent for renewable resources through biorefinery. Advantages to this process over ... -
From Nanocontainer to Nanocatalyst: Mechanistic Studies of [2+2] Photodimerization of Coumarin Derivatives within Cucubit[8]URIL
(North Dakota State University, 2013)Controlling photoreactions remains a formidable challenge to chemists who have developed several approaches with varying degrees of success to achieve high reactivity/selectivity. Following nature's footprints, chemists ... -
Functionalization of Heterocycles: A Metal Catalyzed Approach via Allylation and C-H Activation
(North Dakota State University, 2018)The central core of many biologically active natural products and pharmaceuticals contain N-heterocycles, the installation of simple/complex functional groups using C-H/N-H functionalization methodologies has the potential ... -
Fundamental Surface Properties and Gas-Surface Interactions of Two-Dimensional Materials
(North Dakota State University, 2019)Heterogeneous model catalysis with supported nanomaterials on ultra-thin two-dimensional films has contributed significantly to improve the existing industrial catalytic processes, as well as to discover novel ways to ... -
Identification of Active Sites in Heterogeneous Catalysis and Surface Chemistry Study of Alkanes Adsorption
(North Dakota State University, 2014)Heterogeneous catalysis is considered the basis of the chemical industry. Surface science investigations on model catalysts have made significant contributions in gaining molecular level understanding of heterogeneously ... -
Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Existence of 16 isoenzymes of CA in the ... -
Influence of Organic and Inorganic Passivation on the Photophysics of Cadmium Chalcogenide and Lead Chalcogenide Quantum Dots
(North Dakota State University, 2020)Quantum dots (QDs) are promising materials for photovoltaic (PV) and light-emitting diode (LED) applications due to their unique properties: photostability, size-tunable absorptivity, and narrow line-width emission. These ... -
Interactions of Light with Organic Chromophores: A Photochemical and Photophysical Investigation
(North Dakota State University, 2018)Over the past century, light has emerged as a useful tool finding utility in various fields such as device fabrication, the medical field, as well as utility as an energy source. Chemist have adopted this abundant energy ... -
Investigating Selected Mechanisms of Modulation of BECN1-mediated Autophagy
(North Dakota State University, 2019)Autophagy is a lysosomal degradation pathway wherein cytoplasmic components not needed by or harmful to the cell are degraded and recycled. BECN homologs are key autophagy proteins consisting of an intrinsically disordered ... -
Investigating the Role of BECN1 Conformationally Flexible Regions and Invariant Cys-x-x-Cys Motifs in Autophagy
(North Dakota State University, 2020)Autophagy is an essential catabolic cellular homeostasis process conserved in all eukaryotes. BECN1, a key autophagy protein involved in autophagosome nucleation, comprises of a large, poorly conserved, N-terminal intrinsically ...