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Now showing items 51-56 of 56
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
(North Dakota State University, 2016)
Due to their intimate roles in survival, longevity as well as pathogenesis via “epigenetic” and “metabolic” regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical ...
Synthesis and Characterization of 2,3-Difunctionalized Thieno[3,4-b]Pyrazine-Based Terthienyls Structure-Function Relationships and Side Chain Tunability
(North Dakota State University, 2014)
The ability to tune the physical, electronic, and optical properties of polymer precursors has garnered a great deal of interest in the conjugated organic materials field. The Rasmussen group has previously demonstrated ...
Lateral Flow Nucleic Acid Biosensor for the Detection of Sexually Transmitted Diseases
(North Dakota State University, 2015)
Nucleic acid detection is of central importance for the diagnosis and treatment of genetic diseases, infectious agents, bio-warfare agents, and drug discovery. Nucleic acid testing for diseases is exclusively performed in ...
Enhanced Sensitivity of Lateral Flow Strip Biosensors Based on Enyzmatic Reaction and Nanomaterials
(North Dakota State University, 2014)
Ultrasensitive detection for trace amount of proteins plays pivotal role in the diagnosis of specific diseases in clinical application, basic discovery research and the improvement of proteomics. Recently, lateral flow ...
Differential Modulation of the Structural and Functional Characteristics of Human Matrix Metalloproteinase Isozymes upon Binding to Different Ligands
(North Dakota State University, 2010)
Matrix metalloproteinases (MMPs) are a family of Zn2
+ -dependent, Ca2
+ -containing
endoproteinases involved in tissue remodeling and degradation of the extracellular matrix
(ECM). Human MMP isozymes are known to be ...
Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)
Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo
enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a
proton. Existence of 16 isoenzymes of CA in the ...