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Development of Quantitative Lateral Flow Strip Biosensors for the Detection of Cancer Biomarkers
(North Dakota State University, 2019)
The detection of cancer biomarkers is of great importance in oncology. Cancer biomarkers can provide diagnostic information which can aid disease screening and early diagnosis. Further, cancer biomarkers can help predict ...
Effect of Surface Ligands and Surface Defects on the Electronic and Optical Properties of Quantum Dots
(North Dakota State University, 2016)
Quantum dots (QDs) have drawn a special attention since recent past due to their properties such as broad range absorption ability, size tunable narrow emission, high extinction coefficients, and charge carriers ability. ...
Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation during DNA Repair and Checkpoint Adaptation in Saccharomyces Cerevisiae
(North Dakota State University, 2018)
In response to DNA damage, a signaling cascade is activated within cells that promotes cell cycle arrest in order to provide adequate time for DNA repair to occur. Replication Factor A (RFA) is an essential, heterotrimeric ...
Investigating Selected Mechanisms of Modulation of BECN1-mediated Autophagy
(North Dakota State University, 2019)
Autophagy is a lysosomal degradation pathway wherein cytoplasmic components not needed by or harmful to the cell are degraded and recycled. BECN homologs are key autophagy proteins consisting of an intrinsically disordered ...
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)
Alkynes are versatile and valuable synthetic precursors in a variety of organic
transformations and have found tremendous applications in materials science and pharmaceutical
chemistry. In recent years, there has been a ...
Stereospecific Photochemical Transformations Involving Axially Chiral Acrylanilides and a-Oxoamides
(North Dakota State University, 2013)
Asymmetric photochemical transformations have been under-explored due to the ineffectiveness of conventional methodologies/reagents/catalysts (point chiral auxiliaries and inductors) that were generally employed for thermal ...
Surface Chemistry Characterization of Hydrodesulfurization and Methanol Synthesis Model Nanocatalysts
(North Dakota State University, 2012)
Surface science investigations of model catalysts have contributed significantly to heterogeneous catalysis over the past several decades. The unique properties of nanomaterials are being exploited in catalysis for the ...
Identification of Active Sites in Heterogeneous Catalysis and Surface Chemistry Study of Alkanes Adsorption
(North Dakota State University, 2014)
Heterogeneous catalysis is considered the basis of the chemical industry. Surface science investigations on model catalysts have made significant contributions in gaining molecular level understanding of heterogeneously ...
New Strategies for Ruthenium Catalyzed C-C Bond Formation
(North Dakota State University, 2014)
Transition metal-catalyzed C-H bond activation allows direct functionalization of the ubiquitous C-H bonds in organic molecules to increase the molecular complexity. Since Murai's pioneering work in ruthenium catalyzed ...
Visual Detection of Cancer Biomarkers with Aptamer-Functionalized Gold Nanoparticles
(North Dakota State University, 2015)
Cancer biomarkers may hold the key for the early detection of cancer, distinguishing between benign and malignant cells, and differentiating tumor types. The detection of cancer biomarkers can be used for cancer diagnosis, ...