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Atropisomeric Chromophores as Catalysts and Substrates for Asymmetric Light Induced Transformations
(North Dakota State University, 2016)
Photochemical transformations hold a unique place as they can provide access to molecules with unique stereochemical and structurally complex scaffolds, thus serving as a complementary approach to thermal transformations. ...
4-Dimethylamino Pyridine (DMAP) Catalyst with Fluxional Chirality: Synthesis and Applications
(North Dakota State University, 2016)
Organocatalysis using small organic molecules to catalyze organic transformations, has
emerged as a powerful synthetic tool that is complementary to metal-catalyzed transformations
and remarkably promote stereoselective ...
Biological Effects of Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (VPAC1) and VPAC2 on Chemotaxis and its Regulation of the Tumor Suppressor Ikaros in Leukemic T Cells
(North Dakota State University, 2012)
One in three children diagnosed with cancer has leukemia. Leukemia patients with mutations in the tumor suppressor transcription factor Ikaros (IK), an anti-leukemic factor that is critical for the development of blood ...
Attempted Total Syntheses of a Novel Lycopodine-Class Alkaloid and (R)-Myricanol, Compounds for the Treatment of Alzheimer's Disease
(North Dakota State University, 2013)
Alzheimer's Disease (AD) is a significant challenge to both the pharmaceutical world as well as the synthetic organic chemistry world. One of the most important problems in this field is the lack of a unified approach to ...
Adsorption Kinetics and Dynamics of Small Molecules on Graphene and Graphene oxide
(North Dakota State University, 2018)
Graphene is an allotrope of carbon composed of sp2 hybridized carbon and arranged into a honeycomb lattice. Graphene is a mechanically strong material (200 times stronger than steel) and has high carrier mobility, high ...
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)
Light is an environmentally benign and renewable source of energy that finds wide application in
the field of science. This dissertation explores two areas of chemistry that utilizes light extensively viz.,
asymmetric ...
Structural Studies of the Mechanism by Which BCL-2 and Beclin Proteins Regulate Autophagy and Apoptosis
(North Dakota State University, 2016)
Autophagy and apoptosis are catabolic pathways essential for homeostasis in all eukaryotes. While autophagy usually promotes cell-survival by enabling degradation and recycling of damaged macromolecules, apoptosis is the ...
Strategic Functionalization of Single Walled Carbon Nanotubes to Manipulate their Electronic and Optical Properties
(North Dakota State University, 2017)
Single-walled carbon nanotubes (SWCNTs) are unique materials that exhibit chirality-specific properties due to their one-dimensional confinement. As a result, they are explored for a wide range of applications including ...
Biophysical Studies of Ligand Binding to Human Histone Deacetylase-8
(North Dakota State University, 2014)
Due to an involvement in various patho-physiological conditions, human histone deacetylases (HDACs) are high priority drug targets for the treatment of several diseases, such as cancer, heart failure, neurodegeneration, ...
Interactions of Light with Organic Chromophores: A Photochemical and Photophysical Investigation
(North Dakota State University, 2018)
Over the past century, light has emerged as a useful tool finding utility in various fields such as device fabrication, the medical field, as well as utility as an energy source. Chemist have adopted this abundant energy ...