Chemistry & Biochemistry Doctoral Work: Recent submissions
Now showing items 21-40 of 67
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Apoptosis-Inducing Factor Mediates Metabolism and Oxidative Stress Signaling through Functionally Uncoupled Mechanisms to the Benefit of Tumorigenesis
(North Dakota State University, 2019)Cancer is one of the leading causes of death in the world, arising when cells accumulate genomic mutations that render them incapable of controlling their own proliferation and survival. While substantial improvements in ... -
Acyl Imidazole : A Promising Template for Asymmetric Lewis and Brønsted Acid Mediated 1,3-Dipolar Cycloadditions
(North Dakota State University, 2011)Construction of chiral complex molecules continues to be a challenge for organic chemists all over the world and to address this challenge numerous methodologies have been developed. 1,3-Dipolar cycloaddition reactions is ... -
Fundamental Surface Properties and Gas-Surface Interactions of Two-Dimensional Materials
(North Dakota State University, 2019)Heterogeneous model catalysis with supported nanomaterials on ultra-thin two-dimensional films has contributed significantly to improve the existing industrial catalytic processes, as well as to discover novel ways to ... -
Thiazole vs. Thiophene: Heterocycle Effects on the Properties of Fused-Ring Conjugated Materials
(North Dakota State University, 2017)Conjugated polymers and related molecular materials comprise a field of materials chemistry focused on the development of semiconducting organic plastics that find use in applications such as organic solar cells and organic ... -
Functionalization of Heterocycles: A Metal Catalyzed Approach via Allylation and C-H Activation
(North Dakota State University, 2018)The central core of many biologically active natural products and pharmaceuticals contain N-heterocycles, the installation of simple/complex functional groups using C-H/N-H functionalization methodologies has the potential ... -
Achiral Templates in Asymmetric Catalysis: Applications in Construction of All Carbon Quaternary Centers
(North Dakota State University, 2018)Conjugated olefins are readily available and inexpensive starting materials and their functionalization offers a rapid access to many important building blocks for organic synthesis. The functionalization of these olefins ... -
Exploitation of Biomass for Applications in Sustainable Materials Science
(North Dakota State University, 2019)Biorefinery may be defined as the process of accessing chemical commodities from living systems; consequently, biomass becomes the antecedent for renewable resources through biorefinery. Advantages to this process over ... -
Biochemical and Epidemiological Analysis of Mycobacterium Avium Subspecies Paratuberculosis and Investigation of its Relationship to Crohn's Disease in Humans
(North Dakota State University, 2011)Background: Crohn's disease is a chronic inflammatory disease of the intestine in humans, with no known cause. Johne's disease is a chronic intestinal disease of ruminants caused by Mycobacterium avium suhspecies ... -
Synthesis, Photophysics, Nonlinear Absorption, and Photodynamic Therapy Study of Iridium(III) Complexes
(North Dakota State University, 2018)Video summarizing a Ph.D. dissertation for a non-specialist audience. -
Understanding Binding-Induced Disorder-to-Order And Conformational Transitions in Proteins that Regulate Autophagy
(North Dakota State University, 2018)Autophagy, a cellular homeostasis process that degrades and recycles cytosolic contents, is regulated at various stages by protein interactions. BECN1 regulates autophagy through interactions with diverse proteins via ... -
Micro-/Nano- Materials Based Ultrasensitive Lateral Flow Nucleic Acid Biosensors
(North Dakota State University, 2017)Ultrasensitive detection of nucleic acids plays a very important role in the field of molecular diagnosis for the detection of various diseases. Lateral flow biosensors (LFB) are convenient, easy-to-use, patient friendly ... -
Adsorption Kinetics and Dynamics of Small Molecules on Graphene and Graphene oxide
(North Dakota State University, 2018)Graphene is an allotrope of carbon composed of sp2 hybridized carbon and arranged into a honeycomb lattice. Graphene is a mechanically strong material (200 times stronger than steel) and has high carrier mobility, high ... -
Late Transition Metal-Catalyst Development for Alkyne Coupling Reactions
(North Dakota State University, 2016)Alkynes are versatile and valuable synthetic precursors in a variety of organic transformations and have found tremendous applications in materials science and pharmaceutical chemistry. In recent years, there has been a ... -
Photons in Action: Asymmetric Synthesis and Polymer Degradation
(North Dakota State University, 2016)Light is an environmentally benign and renewable source of energy that finds wide application in the field of science. This dissertation explores two areas of chemistry that utilizes light extensively viz., asymmetric ... -
Structural Studies of the Mechanism by Which BCL-2 and Beclin Proteins Regulate Autophagy and Apoptosis
(North Dakota State University, 2016)Autophagy and apoptosis are catabolic pathways essential for homeostasis in all eukaryotes. While autophagy usually promotes cell-survival by enabling degradation and recycling of damaged macromolecules, apoptosis is the ... -
Visual Detection of Cancer Biomarkers with Aptamer-Functionalized Gold Nanoparticles
(North Dakota State University, 2015)Cancer biomarkers may hold the key for the early detection of cancer, distinguishing between benign and malignant cells, and differentiating tumor types. The detection of cancer biomarkers can be used for cancer diagnosis, ... -
Lateral Flow Nucleic Acid Biosensor for the Detection of Sexually Transmitted Diseases
(North Dakota State University, 2015)Nucleic acid detection is of central importance for the diagnosis and treatment of genetic diseases, infectious agents, bio-warfare agents, and drug discovery. Nucleic acid testing for diseases is exclusively performed in ... -
Stereospecific Phototransformations of Atropisomeric Chromophores
(North Dakota State University, 2014)Photochemical transformations are unique strategy in synthesis that enables us to access complex and structurally diverse organic scaffolds. However, the challenges in controlling the excited-state to perform stereoselective ... -
Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation during DNA Repair and Checkpoint Adaptation in Saccharomyces Cerevisiae
(North Dakota State University, 2018)In response to DNA damage, a signaling cascade is activated within cells that promotes cell cycle arrest in order to provide adequate time for DNA repair to occur. Replication Factor A (RFA) is an essential, heterotrimeric ... -
Strategic Functionalization of Single Walled Carbon Nanotubes to Manipulate their Electronic and Optical Properties
(North Dakota State University, 2017)Single-walled carbon nanotubes (SWCNTs) are unique materials that exhibit chirality-specific properties due to their one-dimensional confinement. As a result, they are explored for a wide range of applications including ...