Microbiological Sciences Doctoral Work
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Recent Submissions
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Rationally Reconstructed and Attenuated Vaccines for Epidemic Response
(North Dakota State University, 2021)Most of the recent viral outbreaks were caused by highly mutating RNA and single stranded DNA viruses. The availability of safe and effective rapid response vaccines early on in an epidemic situation, along with good vaccine ... -
The Effects of Agricultural Factors on Foodborne Bacterial Pathogen Isolation, Attachment, and Survival
(North Dakota State University, 2020)The pathogens enterohemorrhagic Escherichia coli (EHEC), Salmonella enterica, and Listeria monocytogenes are prominent causes of foodborne illness. If they reach the pre- or post-harvest environment of produce, they can ... -
Transmission and Pathogenesis of Swine Torque-Teno Virus 1 (TTSuV1)
(North Dakota State University, 2019)Torque-teno viruses (TTVs) are small ubiquitous non-enveloped single-stranded circular DNA viruses. Since their discovery in a post-transfusion hepatitis patient, they have been isolated in several vertebrate hosts with ... -
Phenotypic and Genomic Assessment of Listeria monocytogenes Virulence
(North Dakota State University, 2019)Listeria monocytogenes is the etiological agent of listeriosis in humans and ruminants causing bacteremia, central nervous system (CNS) infections, abortion, and gastroenteritis among other clinical outcomes. Recent studies ... -
Interactions of Aspergillus fumigatus and Pseudomonas aeruginosa Contribute to Respiratory Disease Severity and Death
(North Dakota State University, 2019)The lung was recently identified to consist of a complex microenvironment made up of microorganisms that interact with one another and the host cells via direct and indirect interactions. As a result, understanding the ... -
Heterogeneity in Phenotypic Response of Foodborne Pathogens to Control Measures
(North Dakota State University, 2019)Foodborne pathogens are estimated to cause 48 million foodborne illnesses through consumption of contaminated food annually. Designing efficient control measures is vital to reducing foodborne illnesses. The modern trend ... -
RNA Viral Prophylaxis: Problems and Potential Solutions
(North Dakota State University, 2019)Over 80% of the newly emerging infectious diseases are caused by RNA viruses. Major global problems associated with the development of vaccines against the RNA virus are their high genetic and antigenic diversity. Hence, ... -
Characterizing the Impact of Stress Exposure on Survival of Foodborne Pathogens
(North Dakota State University, 2019)Bacterial pathogens transmitted by the fecal-oral route endure several stresses during survival/growth in host and non-host environments. For foodborne pathogens, understanding the range of phenotypic responses to stressors ... -
Investigation of Nutrients as Treatments of Bacterial Biofilms
(North Dakota State University, 2019)Using nutrients bacteria utilize to grow as treatments of bacterial biofilms have been investigated. This dissertation examines the problem of the prevention and treatment of biofilms by: (i) testing the effect of the ... -
Phenotypic and Genotypic Effects of FlhC Mediated Gene Regulation in Escherichia Coli O157:H7
(North Dakota State University, 2011)Escherichia coli (E.coli) 0157:H7, a pathogen belonging to the enterohemorrhagic group of E.coli, has long been a concern to human health. The pathogen causes a myriad of symptoms in humans, ranging from diarrhea and malaise ... -
Genetic Disruption of VIP Signaling Alters Intestinal Microbial Structure and Immunity
(North Dakota State University, 2018)Vasoactive intestinal peptide (VIP) regulates clock gene expression in the brain that synchronizes diurnal feeding behaviors in mammals. In the gastrointestinal (GI) tissues, VIP influences host nutrient absorption from ... -
Gene Expression and Evolution in Escherichia Coli Biofilm
(North Dakota State University, 2014)Biofilms can be defined as a complex aggregation of bacterial communities that involves many gene regulatory mechanisms, as well as evolutionary processes to increase biodiversity. Specific Aim 1 used a gene regulation ... -
Rhomboid Proteases and Surface Adhesins During Cryptosporidium Development
(North Dakota State University, 2013)Cryptosporidium parvum, a primary cause of cryptosporidiosis in humans and livestock worldwide, has a complex life cycle that includes an environmental oocyst stage, and stages of merogony, gametogony, and sporogony that ... -
Inhibition of Fusarium Growth and Trichothecene Accumulation in Grain by Antifungal Compounds from Lactic Acid Bacteria
(North Dakota State University, 2013)Fusarium head blight (FHB) is a widely occurring plant disease, which is caused by fungi in the genus Fusarium. FHB leads to mycotoxin accumulation on grain, which causes food safety risk and economic loss. In addition to ... -
Lung Mucosal Response to Repeated Inhalational Insults with Immunomodulatory Agents in a Murine Model of Fungal Asthma: Airway Epithelium Takes the Center Stage
(North Dakota State University, 2013)Asthma is a debilitating disease of the lungs affecting 235 million people worldwide. Fungus-associated asthma leads to a particularly severe type of disease, and exposure to environmental fungi and their products is ... -
Glycan Triggers of Life Cycle Development in the Apicomplexan Parasite Cryptosporidium
(North Dakota State University, 2017)Cryptosporidium is an apicomplexan parasite that causes the diarrheal disease cryptosporidiosis, an infection that can become chronic and life threating in immunocompromised and malnourished individuals. Development of ...
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