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Biochemical and Cellular Characterization of Replication Factor A (RFA) During Meiosis and The DNA Damage Response in Saccharomyces cerevisiae
(North Dakota State University, 2021)
Replication Factor A (RFA) is an essential heterotrimeric single-stranded DNA (ssDNA) binding complex, comprised of Rfa1, Rfa2, and Rfa3 in Saccharomyces cerevisiae. RFA is required for DNA replication, repair, recombination, ...
Glutathione S-Transferase Pi-1 in Pancreatic Cancer Pathogenesis: Mechanistic Insights Into Its Role in Oxidative Stress, Cell Signaling, and Metabolic Pathways
(North Dakota State University, 2021)
Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related deaths in the US. Although surgery remains the most effective treatment option, only a few PDACs are resectable at diagnosis. ...