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Now showing items 11-17 of 17
Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)
Autophagy, a conserved catabolic process required for cellular homeostasis in
eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to
investigate conformational flexibility of autophagy ...
Nutritional Regulation of Growth Hormone-Stimulated Lipolysis
(North Dakota State University, 2014)
Growth hormone (GH) regulates several physiologic processes in vertebrates, including the promotion of growth, an anabolic process, and mobilization of stored lipid, a catabolic process. Here, we used rainbow trout ...
Immunomodulatory Role of B Lymphocytes and Hyaluronic Acid in a Murine Model of Allergic Asthma
(North Dakota State University, 2012)
In the world today, asthma affects more than 235 million people. The widespread prescription of inhaled corticosteroids—the current gold standard of asthma control medication—allows many asthmatics to live symptom-free and ...
The Role of Platelet-Derived Growth Factor Receptor Signaling in Medulloblastoma Metastasis
(North Dakota State University, 2013)
Medulloblastoma is the most common brain tumor in children and one third of the patients remain incurable. Tumor metastasis is one of the primary reasons for its high mortality rate. Despite evidence of overexpression of ...
The Discovery of a Novel Growth Hormone Receptor and the Nutritional Regulation of the Growth Related Actions of Growth Hormone
(North Dakota State University, 2017)
The growth hormone (GH) family peptides such as GH, prolactin (PRL), and somatolactin (SL) regulate a wide array of physiological actions including but not limited to growth, metabolism, osmoregulation, and lipolysis. These ...
Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction
(North Dakota State University, 2012)
Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability ...
Glutathione S-Transferase Pi-1 in Pancreatic Cancer Pathogenesis: Mechanistic Insights Into Its Role in Oxidative Stress, Cell Signaling, and Metabolic Pathways
(North Dakota State University, 2021)
Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related deaths in the US. Although surgery remains the most effective treatment option, only a few PDACs are resectable at diagnosis. ...