Show simple item record

dc.contributor.authorEjjigu, Nega
dc.description.abstractEVs have much potential as sensitive, novel biomarkers because they represent the status of their cells of origin and can be used to detect cancer earlier than alternative biomarkers. The size of EVs can be determined by tunable resistive pulse sensing (TRPS). However, TRPS is susceptible to environmental noise, including mechanical and electrical noise that limits detection precision. To overcome these noises, an external device was designed, guided by flow simulations, to reduce noises that interfere with TRPS measurements. Both mechanical and electrical environmental noise reductions were observed after using the shield. The study also validated the noise reduction function of the shield by quantifying EVs from different cell origins. This study demonstrates innovation in designing shielding enclosures using composite material to improve the sensitivity of emerging tunable resistive pulse technology to quantify EVs below 200 nm, which is challenging using traditional quantification methods.en_US
dc.publisherNorth Dakota State Universityen_US
dc.rightsNDSU policy 190.6.2en_US
dc.titleNoise Reduction of Tunable Resistive Pulse Sensing for Improved Extracellular Vesicles Profiling in Cancer Detectionen_US
dc.typeThesisen_US
dc.date.accessioned2022-06-28T20:47:16Z
dc.date.available2022-06-28T20:47:16Z
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/10365/32773
dc.rights.urihttps://www.ndsu.edu/fileadmin/policy/190.pdfen_US
ndsu.degreeMaster of Science (MS)en_US
ndsu.collegeEngineeringen_US
ndsu.programBiomedical Engineeringen_US
ndsu.advisorSun, Dali


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record