Data replication is a widely used technique in various systems. For example, it can be employed in large-scale distributed file systems to increase data availability and system reliability, or it can be used in many network models (e.g. data grid, Amazon CloudFront) to reduce access latency and network bandwidth consumption, etc. I study a series of problems that related to the data replication method in Hadoop Distributed File System (HDFS) and in Amazon CloudFront service. Data failure, which is caused by hardware failure or malfunction, software error, human error, is the greatest threat to the file storage system. I present a set of schemes to enhance the efficiency of the current data replication strategy in HDFS thereby improving system reliability and performance. I also study the application replication placement problem based on an Original-Front sever model, and I propose a novel strategy which intends to maximize the profit of the application providers.