This review is focused on B-cell’s role in autoimmunity and was conducted by reading current papers across a variety of journals and compiling the information learned in this process. Specifically, this review paper encompasses an analysis of what autoimmune diseases are, as well as some of the characteristics of autoimmune diseases the introduction section of this paper serves as a crash course on B-cell. The disease write-up is where autoimmune diseases that are affected and mediated by B-cells, such as systemic lupus erythematosus, multiple sclerosis, and Chron’s disease, are explored. The next section will compare the mechanisms behind each of the diseases to explain how B-cells can cause a large variety of symptoms as well as highlight what symptoms overlap and why. Treatment options and current research are covered throughout this paper to display an understanding of how these diseases are combated.