Theoretical models of nonsuicidal self-injury (NSSI; i.e., purposeful destruction of body tissue without suicidal intent) suggest that individuals engage in NSSI in order to regulate intense emotions. However, empirical support for these models is limited. This study attempted to address previous limitations by comparing the emotional response to a mood induction and pain (vs. nonpainful) heat stimulation in individuals with history ofNSSI (vs. no history of NSSI) following a negative mood induction. It was predicted that individuals with a history ofNSSI would have a larger increase in negative emotion following the mood induction, and individuals with a history of NSSI who are exposed to a painful stimuli would have the largest decrease in negative emotions compared to the other three groups. Though the first hypothesis was not supported, the second hypothesis received partial support. Clinical implications and future research directions are discussed.