Research into the antecedents and consequences of successful goal pursuit is reviewed within the framework of a proposed existential intervention for depression. Behavioral perspectives propose that insufficient goal pursuit and concomitant positive reinforcement leads to depressed mood. While substantial research has been conducted examining the relation between goal pursuit and psychological well-being, little research exists regarding strategies for fostering increased motivation for goal pursuit in depressed individuals. This review suggests that novel strategies for increasing goal pursuit motivation can be derived from the existential paradigm of Terror Management Theory (TMT). Past TMT research indicates that reminders of mortality lead to greater valuing of the standards and values of one's cultural worldview. The current study screened a sample of individuals exhibiting depressed mood to examine whether reminders of mortality lead to greater valuing and pursuit of individualized goals. Participants were randomly assigned to mortality salience or control condition and completed depression and well-being measures in a baseline session and a follow-up session two weeks later. Results indicated that reminders of mortality did not lead to greater valuing and pursuit of individualized goals.