This paper presents a framework for investigating the potential effects of radiofrequency (RF) exposure on gene expression and cellular processes. Utilizing Schizosaccharomyces Pombe (S. pombe) as a model organism and specialized equipment to create a standard test environment for continued research in this field. Key methods include environmental monitoring, RF antenna configuration, and power density mapping. Results demonstrate the feasibility of the proposed experimental setup. Future directions involve variations in RF frequency and exposure time, as well as exploring underlying molecular mechanisms. This framework aims to lay the groundwork for future experimentation in this field. It emphasizes the need for rigorous scientific inquiry and highlights the potential implications for understanding biological responses to RF exposure. This work provides a roadmap for further investigation into RF effects on gene expression, facilitating advancements in scientific understanding without conducting an actual experiment.