There has been an increasing effort to employ cardiovascular (CV) and pulmonary models to assist in the study of disease, answer research questions, and study the effects of a medical treatment or device. To properly study the intricate dynamics of the CV and pulmonary systems, a comprehensive model is required to achieve a holistic understanding of its mechanics and view the emergent properties of the complex and dynamic cardiopulmonary system. This study builds on the work of Mauro Ursino et al., by taking their multiple CV and pulmonary models and integrating them together within the scalable environment of MATLAB and Simulink. Multiple published mathematical models were implemented and integrated together within Simulink and MATLAB, its hemodynamics and lung mechanics were verified, and the model was additionally adapted for use simulating an invasive pressure-volume (PV) study of the effects of vascular aging of the aorta on cardiac function and efficiency.