This study examined the frequency with which the typical pre-professional pharmacy student alters his/her academic plan, and ultimately affects the student’s matriculation into the professional program. The empirical relationship between adherence to an initial academic plan and acceptance into the professional program was assessed using a sample population of students at NDSU who declared a pre-pharmacy major between 2009 – 2014. Chi-square test and Fisher exact test were used to assess this relationship. The results identified 15 classes that would be detrimental to matriculation. One class was found to be detrimental to matriculation if the student withdrew from that class. While many pre-pharmacy classes do not appear problematic, there are several classes that are detrimental to or even halt a student’s matriculation into the pharmacy professional program. Academic advisors and other college personnel are encouraged to account for these classes when assisting students in the development of their academic plans.