Browsing Larry (Lawrence) Reynolds - Thesis Committee by Issue Date
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Quantifying Seasonal Variation in Physiological Condition of Adult Franklin's Gull (Luecophaeus Pipixcan) during Nesting
(North Dakota State University, 2011)Understanding seasonal variation in adult physiological condition is important for developing hypotheses on how nest initiation, adult condition, chick development and recruitment are related in Franklin's gull and other ... -
Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction
(North Dakota State University, 2012)Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability ... -
Effects of Environmental Estrogens on the Growth Hormone-Insulin-Like Growth Factor System in Rainbow Trout (Oncorhynchus Mykiss)
(North Dakota State University, 2013)The increasing production, use, and disposal of an expanding array of chemicals that enter the environment pose a serious threat to terrestrial and aquatic animals, as well as to humans. Fish in aquatic habitats are exposed ... -
The Role of Platelet-Derived Growth Factor Receptor Signaling in Medulloblastoma Metastasis
(North Dakota State University, 2013)Medulloblastoma is the most common brain tumor in children and one third of the patients remain incurable. Tumor metastasis is one of the primary reasons for its high mortality rate. Despite evidence of overexpression of ... -
Impacts of Beef Cow Nutrition on Conceptus Development
(North Dakota State University, 2013)Two experiments were conducted to determine the effect of maternal nutrient restriction followed by realimentation during early to mid-gestation on uterine blood flow (BF), maternal performance, and conceptus development ... -
Influence of Maternal Nutrient Intake on Placental Vascular Function in Pregnant Beef Cows
(North Dakota State University, 2014)We hypothesized that global maternal nutrient restriction during early and mid-gestation followed by realimentation in pregnant beef cows would alter placental arterial vascular function. We tested changes in placental ... -
Impacts of Supplemental Arginine on Ewe Reproductive Performance
(North Dakota State University, 2014)The objective of this study was to determine the effects of injectable and oral arginine (Arg) supplementation provided 14 d post-breeding on reproductive performance of fall lambing ewes. Upon estrus detection (d 0) ewes ... -
Biophysical Studies of Ligand Binding to Human Histone Deacetylase-8
(North Dakota State University, 2014)Due to an involvement in various patho-physiological conditions, human histone deacetylases (HDACs) are high priority drug targets for the treatment of several diseases, such as cancer, heart failure, neurodegeneration, ... -
Growth Hormone Mediated Regulation of Osmoregulation in Euryhaline Teleosts
(North Dakota State University, 2014)Within the multitude of fish species that exist on our planet, there are a certain number that possess the unique ability to live in both freshwater (FW) and seawater (SW) environments. This ability, known as euryhalinity, ... -
Implementation of Fourier Repetitive Control in Labview
(North Dakota State University, 2014)This thesis presents position control as well as current (torque) control of a DC servo motor with a periodic input. Position control is achieved by using Fourier repetitive control scheme. Simulation on position control ... -
Effects of Corn Condensed Distillers Solubles Supplementation on Intake, Performance, Rate and Site of Digestion, and Ruminal Fermentation in Cattle Consuming Forage-Based Diets
(North Dakota State University, 2015)Two studies were conducted to determine effect of feeding method and level of corn condensed distillers solubles supplementation on performance of beef cows fed forage-based diets and effects on digestibility and ruminal ... -
Arginine Supplementation Strategies during Gestation: Impacts on Dams and Offspring
(North Dakota State University, 2015)We hypothesize rumen-protected arginine supplementation during gestation will mitigate deleterious offspring effects caused by undernutrition. Experiment 1: non-pregnant ewes were supplemented with rumen-protected arginine ... -
Identification and Characterization of Binding Target Proteins of Cancer Stem Cell Inhibitor Salinomycin in Human Neuroblastoma
(North Dakota State University, 2015)Salinomycin, a widely used anti-coccidial agent, was recently identified as a cancer stem cell (CSC) inhibitor from a library of 16,000 natural and commercial chemical compounds based on its highly selective inhibitory ... -
Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)Autophagy, a conserved catabolic process required for cellular homeostasis in eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to investigate conformational flexibility of autophagy ... -
Maternal Nutritional Plane and Endogenous Retroviral Gene Elements, Pregnancy Hormones, and Placental Vascularity and Angiogenic Factors during the Establishment of Pregnancy in Beef Cattle
(North Dakota State University, 2016)In order to meet the projected food demands by 2050, animal agriculture must increase production of animal products on the same or decreased land area through increased efficiency. Early gestation is one area to increase ... -
The Impact of Digestive Enzymes in the Ruminant Animal
(North Dakota State University, 2016)Understanding the enzymatic activity in ruminant digestive systems is essential for securing adequate growth, reproduction and overall metabolism. In order to evaluate the impact of various nutritional sources and dietary ... -
Effects of Maternal Nutrition on Fructose, Glucose, and Cationic Amino Acid Transporter Expression in Bovine Utero-Placental Tissues from Days 16 to 50 of Gestation
(North Dakota State University, 2016)Poor Maternal nutrition has been implicated to reduce nutrient transport to the conceptus. Therefore, we hypothesized that maternal nutrition and day of gestation would impact mRNA expression of nutrient transporters GLUT1, ... -
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
(North Dakota State University, 2016)Due to their intimate roles in survival, longevity as well as pathogenesis via “epigenetic” and “metabolic” regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical ... -
An Insilico Design of Nanoclay Based Nanocomposites and Scaffolds In Bone Tissue Engineering
(North Dakota State University, 2016)A multiscale in silico approach to design polymer nanocomposites and scaffolds for bone tissue engineering applications is described in this study. This study focuses on the role of biomaterials design and selection, ... -
Towards Identifying the Physical and Molecular Components Involved in Resistance to Leaf Rust Pathogen Puccinia Triticina in Wheat and Barley
(North Dakota State University, 2016)Genetic resistance is the preferred method to reduce yield losses caused by many diseases including wheat leaf rust. However, in many cases host resistance seems to be short-lived. For decades, scientists have tried and ...