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Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)
Autophagy, a conserved catabolic process required for cellular homeostasis in
eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to
investigate conformational flexibility of autophagy ...
Maternal Nutritional Plane and Endogenous Retroviral Gene Elements, Pregnancy Hormones, and Placental Vascularity and Angiogenic Factors during the Establishment of Pregnancy in Beef Cattle
(North Dakota State University, 2016)
In order to meet the projected food demands by 2050, animal agriculture must increase
production of animal products on the same or decreased land area through increased efficiency.
Early gestation is one area to increase ...
The Impact of Digestive Enzymes in the Ruminant Animal
(North Dakota State University, 2016)
Understanding the enzymatic activity in ruminant digestive systems is essential for securing adequate growth, reproduction and overall metabolism. In order to evaluate the impact of various nutritional sources and dietary ...
Effects of Maternal Nutrition on Fructose, Glucose, and Cationic Amino Acid Transporter Expression in Bovine Utero-Placental Tissues from Days 16 to 50 of Gestation
(North Dakota State University, 2016)
Poor Maternal nutrition has been implicated to reduce nutrient transport to the conceptus. Therefore, we hypothesized that maternal nutrition and day of gestation would impact mRNA expression of nutrient transporters GLUT1, ...
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
(North Dakota State University, 2016)
Due to their intimate roles in survival, longevity as well as pathogenesis via “epigenetic” and “metabolic” regulatory mechanisms, sirtuins have gained considerable interest toward undertaking detailed biochemical/biophysical ...
An Insilico Design of Nanoclay Based Nanocomposites and Scaffolds In Bone Tissue Engineering
(North Dakota State University, 2016)
A multiscale in silico approach to design polymer nanocomposites and scaffolds for bone tissue engineering applications is described in this study. This study focuses on the role of biomaterials design and selection, ...
Towards Identifying the Physical and Molecular Components Involved in Resistance to Leaf Rust Pathogen Puccinia Triticina in Wheat and Barley
(North Dakota State University, 2016)
Genetic resistance is the preferred method to reduce yield losses caused by many diseases including wheat leaf rust. However, in many cases host resistance seems to be short-lived. For decades, scientists have tried and ...