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Effects of Environmental Estrogens on the Growth Hormone-Insulin-Like Growth Factor System in Rainbow Trout (Oncorhynchus Mykiss)
(North Dakota State University, 2013)
The increasing production, use, and disposal of an expanding array of chemicals that enter the environment pose a serious threat to terrestrial and aquatic animals, as well as to humans. Fish in aquatic habitats are exposed ...
Structural Studies of BECN1, A Key Autophagy Protein, and Intrinsically Disordered Regions in Autophagy Proteins
(North Dakota State University, 2016)
Autophagy, a conserved catabolic process required for cellular homeostasis in
eukaryotes, is regulated by many proteins. The central goal of my doctoral research is to
investigate conformational flexibility of autophagy ...
The Role of Platelet-Derived Growth Factor Receptor Signaling in Medulloblastoma Metastasis
(North Dakota State University, 2013)
Medulloblastoma is the most common brain tumor in children and one third of the patients remain incurable. Tumor metastasis is one of the primary reasons for its high mortality rate. Despite evidence of overexpression of ...
The Discovery of a Novel Growth Hormone Receptor and the Nutritional Regulation of the Growth Related Actions of Growth Hormone
(North Dakota State University, 2017)
The growth hormone (GH) family peptides such as GH, prolactin (PRL), and somatolactin (SL) regulate a wide array of physiological actions including but not limited to growth, metabolism, osmoregulation, and lipolysis. These ...
Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction
(North Dakota State University, 2012)
Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability ...
Influence of Maternal Nutrient Intake on Placental Vascular Function in Pregnant Beef Cows
(North Dakota State University, 2014)
We hypothesized that global maternal nutrient restriction during early and mid-gestation followed by realimentation in pregnant beef cows would alter placental arterial vascular function. We tested changes in placental ...
Effects of Corn Condensed Distillers Solubles Supplementation on Intake, Performance, Rate and Site of Digestion, and Ruminal Fermentation in Cattle Consuming Forage-Based Diets
(North Dakota State University, 2015)
Two studies were conducted to determine effect of feeding method and level of corn condensed distillers solubles supplementation on performance of beef cows fed forage-based diets and effects on digestibility and ruminal ...
Biological Evaluation of the Associations Between Animal Size, Feeding Behavior, Blood Metabolites and Feed Efficiency in Beef Cattle
(North Dakota State University, 2017)
The biological variation in feed efficiency is regulated by multiple physiological mechanisms relevant to energy use in livestock species. The current study examined the associations between body composition, feeding ...
Maternal Nutritional Plane and Endogenous Retroviral Gene Elements, Pregnancy Hormones, and Placental Vascularity and Angiogenic Factors during the Establishment of Pregnancy in Beef Cattle
(North Dakota State University, 2016)
In order to meet the projected food demands by 2050, animal agriculture must increase
production of animal products on the same or decreased land area through increased efficiency.
Early gestation is one area to increase ...
Impacts of Beef Cow Nutrition on Conceptus Development
(North Dakota State University, 2013)
Two experiments were conducted to determine the effect of maternal nutrient restriction followed by realimentation during early to mid-gestation on uterine blood flow (BF), maternal performance, and conceptus development ...