• Estrogen Receptors Signaling in Airway Smooth Muscles: Role in Intracellular Calcium Regulation and Contractility 

  Sangeeta, Bhallamudi (North Dakota State University, 2021)

  Epidemiological evidence suggests higher incidence and severity of asthma in pre-menopausal women and aging men, suggesting a role of sex steroids, especially estrogen. In this regard, it is not clear whether specific ...

• BKCa-IP3R Decoupling in Hypertension 

  Niloy, Sayeman Islam (North Dakota State University, 2022)

  Hypertension is a significant risk factor for cardiovascular diseases and a leading cause of worldwide morbidity and mortality. Dysregulation of intracellular Ca2+ in vascular smooth muscle (VSM) cells is one major contributor ...

• Understanding the Role of Rage in Cell Adhesion 

  Thiyagarajan, Swetha (North Dakota State University, 2022)

  The Receptor for Advanced Glycation Endproducts (RAGE) is a mammalian specific cell surface receptor. RAGE consists of three extracellular domains (V, C1, and C2), a transmembrane domain, and an intracellular cytoplasmic ...

• Kisspeptins: Airway Remodeling in Asthma 

  Borkar, Niyati (North Dakota State University, 2022)

  Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous ...

• Apelin-APJ Signaling in Hypertensive Coronary Arteries 

  Anto, Santo Kalathingal (North Dakota State University, 2022)

  Apelin is an endogenous ligand for APJ receptors, which are highly expressed throughout the cardiovascular system, including coronary arteries. Apelin causes endothelium‐derived nitric oxide (NO) –dependent relaxation ...

• Development of Nano-Architecture Systems for High-Efficiency Tumor-Targeted Drug Delivery 

  Mamnoon, Babak (North Dakota State University, 2021)

  Breast cancer is the most common malignancy and the second leading cause of death among women in the United States. The commonly used breast cancer treatment strategies include surgery, chemotherapy, radiation, and hormonal ...

• Targeted Three-Way-Junction RNA Nanoparticle Reprogrammed Cyclooxygenase-2 Catalyzed Dihomo-ϒ-Linolenic Acid Peroxidation Pattern in Lung Cancer 

  Pang, Lizhi (North Dakota State University, 2021)

  As the second most common cancer and the first leading cause of cancer deaths, lung cancer attracts much research attention. Since cyclooxygenase-2 (COX-2) is overexpressing in nearly 80% of lung cancer patients, COX-2 ...

• Chemical Modification of Bovine Milk Exosomes, the Biological Nanoparticles of the Future, as a Contrast Agent and Drug Delivery Vehicle 

  Pullan, Jessica Elaine (North Dakota State University, 2021)

  Chemically derived nanoparticles are widely used across many applications. While they showed great promise when first discovered, the main hurdles, such as clearance and targeting, have yet to be overcome. A recently ...

• Determination of Growth Inhibitory Effect of Iminodibenzyl Against Breast Cancer 

  Shah, Harshit Pareshbhai (North Dakota State University, 2021)

  Breast cancer arises from the culmination of complex process enclosing multiple gene modifications such as cyclooxygenase-2 (COX-2). It catalyzes arachidonic acid (AA, downstream ω-6 polyunsaturated fatty acid (ω-6 PUFA)) ...

• GLUT-1 Targeted Gene Delivery to Brain for the Treatment of Alzheimer's Disease 

  Arora, Sanjay (North Dakota State University, 2021)

  Alzheimer’s disease (AD) is a neurodegenerative disorder resulting in debilitating dementia with progressive loss of motor functions. Genetic modulation of neurotrophic factors and apolipoprotein E (ApoE) have emerged as ...

• Understanding the Role of Receptor for Advanced Glycation Endproducts (RAGE) in Pancreatic Cancer and Melanoma 

  Taneja, Sakshi (North Dakota State University, 2021)

  In this project we study the role of RAGE in the melanoma and pancreatic cancer progression. Based on published studies, we hypothesized that RAGE localization in melanoma varies with different cellular architectures. To ...

• Antibiotic Releasing Bone-Void Filler for the Treatment of Osteomyelitis: An Approach to Treat Infection and Aid Bone Regeneration 

  Hasan, Mohammad Raquibul (North Dakota State University, 2020)

  Osteomyelitis or bone infections remain very difficult to treat despite advances in treatment regimens and surgical technics. The bone microenvironment and compromised vasculature in addition to infected prosthesis and ...

• Modifications of Recombinant Spider Silk Protein for Various Biomedical Applications 

  Mulinti, Pranothi (North Dakota State University, 2020)

  Silk is a natural protein produced by members of the class Arachnida (over 30,000 species of spiders) and by several worms. Silk-based materials have been investigated for medical and biotechnological applications for many ...

• Drug Delivery Systems for Treatment of Diabetes Mellitus 

  Sharma, Divya (North Dakota State University, 2019)

  Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive ...

• A Nano-Sized Approach to Exploiting the Pancreatic Tumor Microenvironment 

  Confeld, Matthew Ian (North Dakota State University, 2020)

  Making up just over 3% of all new cancer cases in the United States, pancreatic cancer is not inherently a common malignant disease. Yet, it continuously is shown to be one of the most lethal and common causes of cancer ...

• The Role of the Gut Microbiota in Sustained Weight Loss Following Roux-en-Y Gastric Bypass Surgery 

  Fouladi, Farnaz (North Dakota State University, 2018)

  Roux-en-Y Gastric Bypass (RYGB) surgery is one of the most effective approaches for the treatment of severe obesity. Despite substantial weight loss following RYGB, a considerable proportion of patients experience weight ...

• Understanding the Role of the Receptor for Advanced Glycation End-Products (Rage) in Pancreatic Cancer 

  Swami, Priyanka (North Dakota State University, 2019)

  Expression of the Receptor for Advanced Glycation End Products (RAGE) and is upregulated in a several cancers. Based on published studies, we hypothesized that RAGE, when overexpressed in pancreatic cancer cells, will ...

• Evaluation of Smart Polymers for Controlled Release Delivery Systems 

  Lipp, Lindsey (North Dakota State University, 2019)

  Our goal was to develop a smart polymer, controlled release delivery system and evaluate its capabilities for use with salmon calcitonin and rivastigmine. Thermosensitive and phase sensitive smart polymers were evaluated ...

• Dual-Functionalized Liposomes for Gene Delivery to Brain to Prevent and Treat Alzheimer’s Disease 

  dos Santos Rodrigues, Bruna (North Dakota State University, 2019)

  Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder which lacks effective disease-modifying therapies. We have investigated the therapeutic potential of pDNA encoding apolipoprotein E2 (ApoE2), ...

• Dual Functionalized Liposomes for Co-delivery of Anti-cancer Chemotherapeutics for Treatment of Brain Tumor 

  Lakkadwala, Sushant (North Dakota State University, 2019)

  Glioblastoma is a hostile brain tumor associated with high infiltration leading to poor prognosis. Currently available treatment options are insufficient to increase median survival time. The combination therapy has emerged ...

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