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Apelin-APJ Signaling in Hypertensive Coronary Arteries
(North Dakota State University, 2022)
Apelin is an endogenous ligand for APJ receptors, which are highly expressed throughout
the cardiovascular system, including coronary arteries. Apelin causes endothelium‐derived nitric
oxide (NO) –dependent relaxation ...
Kisspeptins: Airway Remodeling in Asthma
(North Dakota State University, 2022)
Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous ...
Understanding the Role of Rage in Cell Adhesion
(North Dakota State University, 2022)
The Receptor for Advanced Glycation Endproducts (RAGE) is a mammalian specific cell surface receptor. RAGE consists of three extracellular domains (V, C1, and C2), a transmembrane domain, and an intracellular cytoplasmic ...
BKCa-IP3R Decoupling in Hypertension
(North Dakota State University, 2022)
Hypertension is a significant risk factor for cardiovascular diseases and a leading cause of worldwide morbidity and mortality. Dysregulation of intracellular Ca2+ in vascular smooth muscle (VSM) cells is one major contributor ...