Pharmacy: Recent submissions
Now showing items 41-51 of 51
-
Elicit Anti-Cancer Effects of Dihomo-γ-linolenic Acid by Exploiting Overexpressed COX-2 in Cancer: Development of an ω-6 Fatty Acid-Based Therapeutic Strategy for Pancreatic Cancer
(North Dakota State University, 2017)Video summarizing Ph.D. dissertation for a non-specialist audience. -
Fluorescent Polymer Based Post-Translational Differentiation and Subtyping of Cancer Cells
(North Dakota State University, 2012)The field of personalized medicine is focused on gathering information at a pre-translational level. Although this information is useful, it is becoming increasingly apparent that post-translational expression is not always ... -
The Potential Inhibitory Effect of Dihomo-Gamma-Linolenic Acid on Colon Cancer Cell Growth via Free Radical Metabolites in Cyclooxygenase-Catalyzed Peroxidation
(North Dakota State University, 2012)Cyclooxygenase (COX) can metabolize dihomo-γ-linolenic acid (DGLA) and arachidonic acid (AA) through free radical-mediated lipid peroxidation to form the anti-carcinogenic 1-series of prostaglandins and pro-carcinogenic ... -
Inhibition of Nitric Oxide Signaling by Melatonin in Porcine Coronary Arteries
(North Dakota State University, 2012)This research represents an effort to bridge a critical gap in the understanding of the local effects of melatonin on the coronary circulation. The first objective was designed to identify the specific melatonin receptor ... -
Detection of Metalloenzymes Employing Fluorescentpolymers and Liposomes
(North Dakota State University, 2012)In the biological systems, proteins are important constituents. Protein-protein interactions play vital roles in physiological environments and any disruption in these interactions lead to adverse effects. However, designing ... -
Effect of Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids on Alcoholic Liver Disease
(North Dakota State University, 2012)PUFAs have been shown to modulate ALD by several mechanisms, including free radical generation from hepatic lipid peroxidation. However, how they modulate lipid peroxidation and generation of bioactive metabolites in ALD ... -
Development of a Novel Omega-6 Fatty Acid Based Treatment Strategy for Colon Cancer by Knocking Down Delta-5-Desaturase and Exploiting High COX-2 Levels in Cancer CellsTumors
(North Dakota State University, 2017)Colon cancer is the third most commonly diagnosed cancer in the world. Research showed that arachidonic acid, a downstream ω-6 fatty acid (ω-6), plays a role in colon cancer development by producing deleterious metabolites ... -
Interactions of the Receptor for Advanced Glycation End Products (Rage) with Advanced Glycation End Products (AGEs) and S100B
(North Dakota State University, 2016)RAGE is a multi-ligand pattern recognition receptor. RAGE can bind several damage associated molecular pattern proteins. RAGE- ligand interaction is pathophysiologically relevant to several major diseases including diabetes ... -
Design and Development of Tumor Microenvironment Responsive PEGylated Nanoparticles for Drug Delivery to Cancerous Solid Tumors
(North Dakota State University, 2016)Rapid growth of cancerous cells creates a biochemically distinct microenvironment in solid tumors. Leaky vasculature, lower pH, increased levels of proteolytic enzymes, hypoxia serve as hallmarks of tumor tissues. These ... -
Role of Large Conductance, Calcium-Activated Potassium Channels (BKCa) in Vasorelaxation of Nitrate Tolerant Mesenteric Arteries
(North Dakota State University, 2016)Video summarizing Ph.D. dissertation for a non-specialist audience. -
Identification and Characterization of Binding Target Proteins of Cancer Stem Cell Inhibitor Salinomycin in Human Neuroblastoma
(North Dakota State University, 2015)Salinomycin, a widely used anti-coccidial agent, was recently identified as a cancer stem cell (CSC) inhibitor from a library of 16,000 natural and commercial chemical compounds based on its highly selective inhibitory ...