Browsing Chemistry & Biochemistry by Issue Date
Now showing items 1-20 of 90
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Diastereoselective Conjugate Radical Additions to ~-Pyrones
(North Dakota State University, 2009)A convenient protocol for functionalization of ~-pyrones has been developed. Conjugate radical addition and tandem addition-trapping protocols allowed accessing highly substituted pyrones in a single operation with high ... -
Synthesis and Photophysics of Platinum(II) Terdentate and Bidentate Complexes.
(North Dakota State University, 2010)Platinum(ll) terdentate and bidentate complexes possess square-planar d8 configuration. The moderate metal-to-ligand charge-transfer (1MLCT) absorption, 3MLCT emission, and broadband excited-state absorption are the ... -
Interactions of Synthetic Metal Porphyrinates with PhuS, a Cytoplasmic Heme Trafficking Protein from Pseudomonas aeruginosa
(North Dakota State University, 2010)Pseudomonas aeruginosa is an opportunistic, Gram negative, bacterial pathogen that commonly establishes infection in immunocompromised individuals. It contains protein-based, iron uptake pathways that target both heme ... -
Differential Modulation of the Structural and Functional Characteristics of Human Matrix Metalloproteinase Isozymes upon Binding to Different Ligands
(North Dakota State University, 2010)Matrix metalloproteinases (MMPs) are a family of Zn2 + -dependent, Ca2 + -containing endoproteinases involved in tissue remodeling and degradation of the extracellular matrix (ECM). Human MMP isozymes are known to be ... -
Regioselective and Enantioselective Nitrone Cycloadditions to Alkynones.
(North Dakota State University, 2010)There has been a need in agriculture, medicine, and organic chemistry for enantiopure isoxazolines. A direct method for their synthesis is from the cycloaddition of 1,3-dipoles and alkynes. Alkynones are difficult ... -
Influence of Active Site Ligands and Nanoparticle Surfaces on Human Carbonic Anhydrase Isozymes
(North Dakota State University, 2010)Carbonic anhydrase (CA) is an ubiquitously distributed zinc containing metallo enzyme that catalyzes the reversible hydration of carbon dioxide to form bicarbonate and a proton. Existence of 16 isoenzymes of CA in the ... -
Acyl Imidazole : A Promising Template for Asymmetric Lewis and Brønsted Acid Mediated 1,3-Dipolar Cycloadditions
(North Dakota State University, 2011)Construction of chiral complex molecules continues to be a challenge for organic chemists all over the world and to address this challenge numerous methodologies have been developed. 1,3-Dipolar cycloaddition reactions is ... -
Biochemical and Epidemiological Analysis of Mycobacterium Avium Subspecies Paratuberculosis and Investigation of its Relationship to Crohn's Disease in Humans
(North Dakota State University, 2011)Background: Crohn's disease is a chronic inflammatory disease of the intestine in humans, with no known cause. Johne's disease is a chronic intestinal disease of ruminants caused by Mycobacterium avium suhspecies ... -
The Optimization of Whole Genome Amplification and Molecular Crowding for Use in Forensic Low Copy Number Samples
(North Dakota State University, 2011)Whole genome amplification has been used as a powerful tool to increase the amount of DNA template used for microarrays, STR and SNP assays in clinical and forensic settings. Our laboratory observed that multiple displacement ... -
Stereoselective Carbon-Carbon Bond Construction Using Indium and Bismuth: New Methods in Green Chemistry
(North Dakota State University, 2012)Selective chemical reactions that can be accomplished with minimal waste using non-toxic catalysts and reagents will allow for new greener chemical processes for future environmentally sustainable technologies. This work ... -
Biological Effects of Vasoactive Intestinal Peptide/Pituitary Adenylate Cyclase Activating Polypeptide Receptor 1 (VPAC1) and VPAC2 on Chemotaxis and its Regulation of the Tumor Suppressor Ikaros in Leukemic T Cells
(North Dakota State University, 2012)One in three children diagnosed with cancer has leukemia. Leukemia patients with mutations in the tumor suppressor transcription factor Ikaros (IK), an anti-leukemic factor that is critical for the development of blood ... -
Surface Chemistry Characterization of Hydrodesulfurization and Methanol Synthesis Model Nanocatalysts
(North Dakota State University, 2012)Surface science investigations of model catalysts have contributed significantly to heterogeneous catalysis over the past several decades. The unique properties of nanomaterials are being exploited in catalysis for the ... -
Attempted Total Syntheses of a Novel Lycopodine-Class Alkaloid and (R)-Myricanol, Compounds for the Treatment of Alzheimer's Disease
(North Dakota State University, 2013)Alzheimer's Disease (AD) is a significant challenge to both the pharmaceutical world as well as the synthetic organic chemistry world. One of the most important problems in this field is the lack of a unified approach to ... -
Supramolecular Functionalization of Single-Walled Carbon Nanotubes
(North Dakota State University, 2013)Single-walled carbon nanotubes (SWNTs) possess extraordinary mechanical strength, thermal and electrical conductivity. These properties make them very attractive in many applications in the fields of nanotechnology, ... -
Stereospecific Photochemical Transformations Involving Axially Chiral Acrylanilides and a-Oxoamides
(North Dakota State University, 2013)Asymmetric photochemical transformations have been under-explored due to the ineffectiveness of conventional methodologies/reagents/catalysts (point chiral auxiliaries and inductors) that were generally employed for thermal ... -
From Nanocontainer to Nanocatalyst: Mechanistic Studies of [2+2] Photodimerization of Coumarin Derivatives within Cucubit[8]URIL
(North Dakota State University, 2013)Controlling photoreactions remains a formidable challenge to chemists who have developed several approaches with varying degrees of success to achieve high reactivity/selectivity. Following nature's footprints, chemists ... -
Mechanistic Studies on the Methionine Aminopeptidase and Peptide Deformylase Catalyzed Reactions
(North Dakota State University, 2013)In the search for novel antibiotic and therapeutic targets, methionine aminopeptidase (MetAP) and peptide deformylase (PDF) have recently been identified as eminently compelling. These enzymes are involved in the ... -
Exciton Diffusion, Transport, and Localization in Conjugated Polymers
(North Dakota State University, 2013)Conjugated polymers are wide bandgap semiconductors which have a series of conjugated π-orbitals that extend along the polymer ‘backbone’. The π-orbital conjugation can be disrupted by twisting of the polymer, affecting ... -
Identification of Novel RPA-Protein Interactions Using the Yeast Two Hybrid Assay and Identification of Regions Important for Interaction Between RPA and Rad24
(North Dakota State University, 2013)Replication Protein A (RPA) [Replication Factor A (RFA) in yeast] is an ssDNA binding protein composed of Rpa1, Rpa2, and Rpa3 and involved in numerous DNA processing pathways such as Replication, Recombination, and Repair. ... -
Synthesis, Characterization, and Application of Low and Reduced Band Gap Thieno[3,4-b]pyrazine-based Materials
(North Dakota State University, 2013)Conjugated polymers are a class of materials receiving significant interest due to their unique combination of optical and electronic properties found in inorganics with the flexibility and processability of traditional ...